(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Base Information

Chemical Name:(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester
CAS No.:81087-39-0
Molecular Formula:C₄₄H₄₃ClN₃O₁₀P
Molecular Weight:840.266
Hs Code.:

(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Synonyms:(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

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Chemical Property of (4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

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Technology Process of (4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

There total 3 articles about (4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 81087-19-6
p-chlorophenyl N-(p-methoxyphenyl)chlorophosphoramidate

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 81087-39-0
(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Guidance literature:: With 1-methyl-1H-imidazole; In 1,4-dioxane; at 25 ℃; for 2h;
DOI:10.1248/cpb.29.3440

Reference yield:

: 104-94-9
4-methoxy-aniline

: 81087-39-0
(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / diethyl ether; benzene / 6 h / Ambient temperature

2: 98 percent / 1-methyl imidazole / dioxane / 2 h / 25 °C

With 1-methyl-1H-imidazole; In 1,4-dioxane; diethyl ether; benzene;
DOI:10.1248/cpb.29.3440

Reference yield:

: 772-79-2
4-chlorophenylphosphorodichloridate

: 81087-39-0
(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / diethyl ether; benzene / 6 h / Ambient temperature

2: 98 percent / 1-methyl imidazole / dioxane / 2 h / 25 °C

With 1-methyl-1H-imidazole; In 1,4-dioxane; diethyl ether; benzene;
DOI:10.1248/cpb.29.3440