2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

Base Information

Chemical Name:2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol
CAS No.:333743-74-1
Molecular Formula:C₁₆H₁₇FN₄O₂S₂
Molecular Weight:380.467
Hs Code.:

Synonyms:2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

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Chemical Property of 2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

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Technology Process of 2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

There total 7 articles about 2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 67-56-1
methanol

: 333743-73-0
2-[[2-bromo-5-[[(2-fluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

: 333743-74-1
2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

Guidance literature:: With potassium hydroxide;
DOI:10.1016/j.bmcl.2007.11.039

Reference yield:

: 333742-99-7
(R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

: 333743-74-1
2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia; sodium; ammonium chloride

2.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide / 1 h / 50 °C

3.1: Bromoform; isopentyl nitrite / acetonitrile / 0.17 h / 50 °C

4.1: potassium hydroxide / methanol / 24 h

4.2: pH 7

With potassium hydroxide; Bromoform; ammonia; sodium; ammonium chloride; N-ethyl-N,N-diisopropylamine; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; methanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 333743-72-9
2-[[2-amino-5-[[(2-fluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

: 333743-74-1
2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: Bromoform; isopentyl nitrite / acetonitrile / 0.17 h / 50 °C

2.1: potassium hydroxide / methanol / 24 h

2.2: pH 7

With potassium hydroxide; Bromoform; isopentyl nitrite; In methanol; acetonitrile;