Technology Process of [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride
There total 10 articles about [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 76 percent / Et3N / CH2Cl2 / 2 h / Heating
2: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h
3: 48 percent / H2 / 10percent Pd/C / ethanol / 16 h / Ambient temperature
4: 56 percent / LiAlH4 / tetrahydrofuran / 16 h / Heating
5: 87 percent / Et4NBr, aq. NaOH / CH2Cl2 / 72 h
6: 100 percent / CF3CO2H / CH2Cl2 / 72 h
7: (COCl)2, DMF / CH2Cl2 / 16 h / Ambient temperature
With
sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; tetraethylammonium bromide; hydrogen; sodium hydride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-1996-4319
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 80 percent / NH2NH2*H2O / 10percent Pd/C / ethanol / 1 h / Heating
2: 76 percent / Et3N / CH2Cl2 / 2 h / Heating
3: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h
4: 48 percent / H2 / 10percent Pd/C / ethanol / 16 h / Ambient temperature
5: 56 percent / LiAlH4 / tetrahydrofuran / 16 h / Heating
6: 87 percent / Et4NBr, aq. NaOH / CH2Cl2 / 72 h
7: 100 percent / CF3CO2H / CH2Cl2 / 72 h
8: (COCl)2, DMF / CH2Cl2 / 16 h / Ambient temperature
With
sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; tetraethylammonium bromide; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-1996-4319
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h
2: 48 percent / H2 / 10percent Pd/C / ethanol / 16 h / Ambient temperature
3: 56 percent / LiAlH4 / tetrahydrofuran / 16 h / Heating
4: 87 percent / Et4NBr, aq. NaOH / CH2Cl2 / 72 h
5: 100 percent / CF3CO2H / CH2Cl2 / 72 h
6: (COCl)2, DMF / CH2Cl2 / 16 h / Ambient temperature
With
sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; tetraethylammonium bromide; hydrogen; sodium hydride; N,N-dimethyl-formamide; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-1996-4319
