[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride

Base Information

• Chemical Name: [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride
• CAS No.: 181725-58-6
• Molecular Formula: C₃₈H₄₂Cl₂N₂O₇
• Molecular Weight: 709.667

Synonyms:[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride

Chemical Property of [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride

There total 10 articles about [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(2-aminophenyl)ether (24878-25-9) → [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride (181725-58-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

2: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

3: 48 percent / H₂ / 10percent Pd/C / ethanol / 16 h / Ambient temperature

4: 56 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

5: 87 percent / Et₄NBr, aq. NaOH / CH₂Cl₂ / 72 h

6: 100 percent / CF₃CO₂H / CH₂Cl₂ / 72 h

7: (COCl)2, DMF / CH₂Cl₂ / 16 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; tetraethylammonium bromide; hydrogen; sodium hydride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-1996-4319

Reference yield:

bis(2-nitrophenyl)ether (2217-65-4) → [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride (181725-58-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 80 percent / NH₂NH₂*H₂O / 10percent Pd/C / ethanol / 1 h / Heating

2: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

3: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

4: 48 percent / H₂ / 10percent Pd/C / ethanol / 16 h / Ambient temperature

5: 56 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

6: 87 percent / Et₄NBr, aq. NaOH / CH₂Cl₂ / 72 h

7: 100 percent / CF₃CO₂H / CH₂Cl₂ / 72 h

8: (COCl)2, DMF / CH₂Cl₂ / 16 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; tetraethylammonium bromide; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-1996-4319

Reference yield:

2-(2-Benzyloxy-ethoxy)-N-(2-{2-[2-(2-benzyloxy-ethoxy)-acetylamino]-phenoxy}-phenyl)-acetamide (181725-46-2) → [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride (181725-58-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

2: 48 percent / H₂ / 10percent Pd/C / ethanol / 16 h / Ambient temperature

3: 56 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

4: 87 percent / Et₄NBr, aq. NaOH / CH₂Cl₂ / 72 h

5: 100 percent / CF₃CO₂H / CH₂Cl₂ / 72 h

6: (COCl)2, DMF / CH₂Cl₂ / 16 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; tetraethylammonium bromide; hydrogen; sodium hydride; N,N-dimethyl-formamide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-1996-4319

upstream raw materials:

[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid

bis(2-nitrophenyl)ether

bis(2-aminophenyl)ether

ortho-nitrofluorobenzene

Downstream raw materials:

N-{2-[2-(2-Methoxy-acetylamino)-phenoxy]-phenyl}-2-(2-{2-[2-(2-{2-[2-({2-[2-(2-methoxy-acetylamino)-phenoxy]-phenylcarbamoyl}-methoxy)-ethoxy]-ethylamino}-phenoxy)-phenylamino]-ethoxy}-ethoxy)-acetamide

2-{2-[2-(Benzyl-{2-[2-(benzyl-{2-[2-({2-[2-(2-methoxy-acetylamino)-phenoxy]-phenylcarbamoyl}-methoxy)-ethoxy]-ethyl}-amino)-phenoxy]-phenyl}-amino)-ethoxy]-ethoxy}-N-{2-[2-(2-methoxy-acetylamino)-phenoxy]-phenyl}-acetamide

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