[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid

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Chemical Name:[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid
CAS No.:181725-56-4
Molecular Formula:C₃₈H₄₄N₂O₉
Molecular Weight:672.775
Hs Code.:

Synonyms:[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid

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Chemical Property of [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid

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Technology Process of [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid

There total 8 articles about [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 181725-54-2
[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester

: 181725-56-4
[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 72h;
DOI:10.1055/s-1996-4319

Reference yield:

: 24878-25-9
bis(2-aminophenyl)ether

: 181725-56-4
[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

2: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

3: 48 percent / H₂ / 10percent Pd/C / ethanol / 16 h / Ambient temperature

4: 56 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

5: 87 percent / Et₄NBr, aq. NaOH / CH₂Cl₂ / 72 h

6: 100 percent / CF₃CO₂H / CH₂Cl₂ / 72 h

With sodium hydroxide; lithium aluminium tetrahydride; tetraethylammonium bromide; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-1996-4319

Reference yield:

: 2217-65-4
bis(2-nitrophenyl)ether

: 181725-56-4
[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / NH₂NH₂*H₂O / 10percent Pd/C / ethanol / 1 h / Heating

2: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

3: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

4: 48 percent / H₂ / 10percent Pd/C / ethanol / 16 h / Ambient temperature

5: 56 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

6: 87 percent / Et₄NBr, aq. NaOH / CH₂Cl₂ / 72 h

7: 100 percent / CF₃CO₂H / CH₂Cl₂ / 72 h

With sodium hydroxide; lithium aluminium tetrahydride; tetraethylammonium bromide; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-1996-4319