2217-65-4

Basic information

• Product Name: Benzene, 1,1'-oxybis[2-nitro-
• CAS NO: 2217-65-4
• Molecular Formula: C12H8N2O5
• Molecular Weight: 260.206
• Mol File: 2217-65-4.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Benzene, 1,1'-oxybis[2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,1'-oxybis[2-nitro-(2217-65-4)
• EPA Substance Registry System: Benzene, 1,1'-oxybis[2-nitro-(2217-65-4)

Safety Data

• Hazardous Substances Data: 2217-65-4(Hazardous Substances Data)

Usage

General Description

Benzene, 1,1'-oxybis[2-nitro- is a chemical compound consisting of benzene with two nitro groups attached to an oxygen atom bridged between two carbon atoms. It is commonly used as a chemical intermediate in the production of various organic compounds, including dyes, pesticides, and pharmaceuticals. The compound is highly flammable and can cause irritation to the skin, eyes, and respiratory system upon exposure. In addition, it is considered to be a potential carcinogen, with long-term exposure being linked to an increased risk of developing cancer. Due to its hazardous nature, proper safety precautions and handling procedures should be followed when working with this chemical.

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 100-02-7 4-nitro-phenol 
• 126813-47-6 N-<2-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-N-methyl-4-chloro-3-nitrobenzenesulfonamide 
• 88-75-5 2-hydroxynitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 81420-42-0 mononitrophenyl carbonate 
• 151-50-8 potassium cyanide 
• 528-29-0 1,2-Dinitrobenzene 
• 298-14-6 potassium hydrogencarbonate 
• 95-56-7 2-hydroxybromobenzene 
• 101-84-8 diphenylether 
• 27122-72-1 Hexakis-<2-nitro-phenoxy>-cyclotriphosphonitril 
• 55144-24-6 2-nitro-phenol; potassium-compound 
• 824-38-4 potassium 2-nitrophenoxide 

Downstream Products

• 2592-95-2 benzotriazol-1-ol 
• 88-75-5 2-hydroxynitrobenzene 
• 98-95-3 nitrobenzene 
• 135685-02-8 N-(2-Dimethylaminoethyl)-N-methyl-4-(4-nitrophenoxy)-3-nitrobenzenesulfonamide 
• 76967-88-9 N,N'-(2,2'-oxybis(2,1-phenylene))dibenzamide 
• 105122-80-3 Bis--5-nitro-phenyl>-ether 
• 97657-13-1 -5-(4-nitro-phenylazo)-phenyl>--phenyl>-ether 
• 107158-58-7 Bis--phenyl>-ether 
• 857477-57-7 bis-(2-thioureido-phenyl)-ether 
• 159428-16-7 O(C₆H₄NP(C₆H₅)3)2 
• 161267-47-6 2,2'-bis(2,2-dimethylacetamido)diphenyl ether 

Relevant articles and documents

A Comprehensive Study of the Ca2+ Ion Binding of Fluorescently Labelled BAPTA Analogues

Since its development, the ionophore BAPTA (1,2-bis(2-aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid) has been used unchanged in calcium sensing applications. In this work we present a comprehensive experimental and theoretical study of novel alterations in the structure of BAPTA, with a focus on the systematic modification of the chain connecting the two aromatic rings of the molecule (denoted as “linker”). A bis-(diethylamino)xantene fluorophore was also attached to the structures in a fixed position and the structure-fluorescence response relationship of these molecules was investigated in addition. The effect of the linker's length, the number of oxygen atoms in this chain and even the removal of one of the rings was tested; these all proved to significantly alter the characteristics of the compounds. For example, it was found that the second aromatic ring of BAPTA is not essential for the turn-on of the fluorescence. We also demonstrated that successful sensing can be realized even by replacing the chain with a single oxygen atom, which suggests the availability of a new calcium binding mode of the chelator. The reliable turn-on characteristic, the steep Ca2+ fluorescence titration curve and the intense fluorescence emission combine to make this compound a prospective candidate as a calcium sensing molecular probe in diagnostic neurobiological applications.

Metal- and Phenol-Free Synthesis of Biaryl Ethers: Access to Dibenzobistriazolo-1,4,7-oxadiazonines and Vancomycin-Like Glyco-Macrocycles as Antibacterial Agents

An efficient synthesis of biaryl ethers, from electron-deficient aryl halides using NaH/DMSO under metal- and phenol-free conditions, has been achieved to access dibenzo-bistriazolo-1,4,7-oxadiazonines and vancomycin-like glyco-macrocycles. A 44-membered glyco-macrocycle showed promising activity against vancomycin-resistant Staphylococcus aureus (VRSA).

Iridium-catalyzed synthesis of diaryl ethers by means of chemoselective C-F bond activation and the formation of B-F bonds

Transition-metal-catalyzed C-F activation, in comparison with C-H activation, is more difficult to achieve and therefore less fully understood, mainly because carbon-fluorine bonds are the strongest known single bonds to carbon and have been very difficult to cleave. Transition-metal complexes are often more effective at cleaving stronger bonds, such as C(sp2)-X versus C(sp2)-X. Here, the iridium-catalyzed C-F activation of fluorarenes was achieved through the use of bis(pinacolato)diboron with the formation of the B-F bond and self-coupling. This strategy provides a convenient method with which to convert fluoride aromatic compounds into symmetrical diaryl ether compounds. Moreover, the chemoselective products of the C-F bond cleavage were obtained at high yields with the C-Br and C-Cl bonds remaining.