Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate

Base Information

Chemical Name:Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate
CAS No.:1232068-93-7
Molecular Formula:C₂₀H₁₃ClFNO₂S
Molecular Weight:385.846
Hs Code.:

Synonyms:Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate

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Chemical Property of Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate

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Technology Process of Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate

There total 3 articles about Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1232068-87-9
Ethyl 4-bromo-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylate

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 1232068-93-7
Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In monoethylene glycol diethyl ether; water; at 80 ℃; Inert atmosphere;

Reference yield:

: 62224-25-3
4,5-dibromothiophene-2-carboxylic acid ethyl ester

: 1232068-93-7
Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 60 °C / Inert atmosphere

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 80 °C / Inert atmosphere

With sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In monoethylene glycol diethyl ether; water; toluene;

Reference yield:

: 2810-04-0
Ethyl thiophene-2-carboxylate

: 1232068-93-7
Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; acetic acid / 60 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 60 °C / Inert atmosphere

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 80 °C / Inert atmosphere

With bromine; sodium hydrogencarbonate; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In monoethylene glycol diethyl ether; water; toluene;