isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate

Base Information

• Chemical Name: isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate
• CAS No.: 1196452-46-6
• Molecular Formula: C₁₈H₁₇IN₂O₂
• Molecular Weight: 420.25
• Mol file: 1196452-46-6.mol

Synonyms:isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate

Chemical Property of isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate

There total 3 articles about isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Isobutyl bromide (78-77-3) + 3-(5-iodo-1H-indazol-1-yl)benzoic acid (1034155-43-5) → isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate (1196452-46-6)

Guidance literature:

With sodium carbonate; In 1-methyl-pyrrolidin-2-one; at 40 - 55 ℃;

DOI:10.1021/acs.jmedchem.7b01215

Reference yield:

3-hydrazinobenzoic acid (38235-71-1) → isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate (1196452-46-6)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1.33 h / 20 °C / Inert atmosphere

2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 0.5 h / 160 °C

3: sodium carbonate / 1-methyl-pyrrolidin-2-one / 40 - 55 °C

With potassium tert-butylate; sodium carbonate; caesium carbonate; In 1-methyl-pyrrolidin-2-one;

DOI:10.1021/acs.jmedchem.7b01215

Reference yield:

2-Fluoro-5-iodo-benzaldehyde (146137-76-0) → isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate (1196452-46-6)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1.33 h / 20 °C / Inert atmosphere

2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 0.5 h / 160 °C

3: sodium carbonate / 1-methyl-pyrrolidin-2-one / 40 - 55 °C

With potassium tert-butylate; sodium carbonate; caesium carbonate; In 1-methyl-pyrrolidin-2-one;

DOI:10.1021/acs.jmedchem.7b01215

upstream raw materials:

Isobutyl bromide

3-(5-iodo-1H-indazol-1-yl)benzoic acid

2-Fluoro-5-iodo-benzaldehyde

3-hydrazinobenzoic acid

Downstream raw materials:

isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

1-({3-[5-({(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-phenylpropyl}oxy)-1H-indazol-1-yl]phenyl}carbonyl)-D-prolinamide

1-({3-[5-({(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-phenylpropyl}oxy)-1H-indazol-1-yl]phenyl}carbonyl)-L-prolinamide

3-[5-({(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-phenylpropyl}poxy)-1H-indazol-1-yl]-N-[(3R)-2-oxotetrahydrofuran-3-yl]benzamide

Refernces

• 1、 -. "PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES". Page/Page column 35; 36. . Retrieved 2009/12/27.