3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoic acid

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Chemical Name:3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoic acid
CAS No.:1196452-42-2
Molecular Formula:C₂₈H₂₉N₃O₅
Molecular Weight:487.555
Hs Code.:

Synonyms:3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoic acid

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Chemical Property of 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoic acid

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Technology Process of 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoic acid

There total 4 articles about 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1196452-43-3
isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

: 1196452-42-2
3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoic acid

Guidance literature:: isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate; With water; sodium hydroxide; In 1,4-dioxane; at 80 ℃; for 1h;

With hydrogenchloride; In water;

Reference yield:

: 1034155-43-5
3-(5-iodo-1H-indazol-1-yl)benzoic acid

: 1196452-42-2
3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / 1-methyl-pyrrolidin-2-one / 40 °C

1.2: 40 - 55 °C

2.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 0.5 h / 85 °C

2.2: 85 °C

3.1: triethylamine / tetrahydrofuran / 0 °C

4.1: water; sodium hydroxide / 1,4-dioxane / 1 h / 80 °C

With water; sodium carbonate; caesium carbonate; triethylamine; sodium hydroxide; copper(l) iodide; dimethylaminoacetic acid; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; propyl cyanide;

Reference yield:

: 1196452-46-6
isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate

: 1196452-42-2
3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 0.5 h / 85 °C

1.2: 85 °C

2.1: triethylamine / tetrahydrofuran / 0 °C

3.1: water; sodium hydroxide / 1,4-dioxane / 1 h / 80 °C

With water; caesium carbonate; triethylamine; sodium hydroxide; copper(l) iodide; dimethylaminoacetic acid; In tetrahydrofuran; 1,4-dioxane; propyl cyanide;