isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

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Chemical Name:isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate
CAS No.:1196452-43-3
Molecular Formula:C₃₂H₃₇N₃O₅
Molecular Weight:543.663
Hs Code.:

Synonyms:isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

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Chemical Property of isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

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Technology Process of isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

There total 3 articles about isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1196452-44-4
isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

: 1196452-43-3
isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 1034155-43-5
3-(5-iodo-1H-indazol-1-yl)benzoic acid

: 1196452-43-3
isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / 1-methyl-pyrrolidin-2-one / 40 °C

1.2: 40 - 55 °C

2.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 0.5 h / 85 °C

2.2: 85 °C

3.1: triethylamine / tetrahydrofuran / 0 °C

With sodium carbonate; caesium carbonate; triethylamine; copper(l) iodide; dimethylaminoacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; propyl cyanide;

Reference yield:

: 1196452-46-6
isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate

: 1196452-43-3
isobutyl 3-(5-((1R,2S)-2-(tert-butoxycarbonylamino)-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 0.5 h / 85 °C

1.2: 85 °C

2.1: triethylamine / tetrahydrofuran / 0 °C

With caesium carbonate; triethylamine; copper(l) iodide; dimethylaminoacetic acid; In tetrahydrofuran; propyl cyanide;