isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

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Chemical Name:isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate
CAS No.:1196452-44-4
Molecular Formula:C₂₇H₂₉N₃O₃
Molecular Weight:443.546
Hs Code.:

Synonyms:isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

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Chemical Property of isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

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Technology Process of isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

There total 6 articles about isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1196452-46-6
isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate

: 492-41-1,58550-13-3,757124-50-8
(1R,2S)-norephedrine

: 1196452-44-4
isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

Guidance literature:: (1R,2S)-norephedrine; With copper(l) iodide; dimethylaminoacetic acid; caesium carbonate; at 110 ℃; for 0.5h;

isobutyl 3-(5-iodo-1H-indazol-1-yl)benzoate; at 110 ℃; for 19h; Sealed tube;
DOI:10.1021/acs.jmedchem.7b01215

Reference yield:

: 1034155-43-5
3-(5-iodo-1H-indazol-1-yl)benzoic acid

: 1196452-44-4
isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / 1-methyl-pyrrolidin-2-one / 40 - 55 °C

2.1: dimethylaminoacetic acid; caesium carbonate; copper(l) iodide / 0.5 h / 110 °C

2.2: 19 h / 110 °C / Sealed tube

With copper(l) iodide; dimethylaminoacetic acid; sodium carbonate; caesium carbonate; In 1-methyl-pyrrolidin-2-one; 2.1: |Ullmann Condensation / 2.2: |Ullmann Condensation;
DOI:10.1021/acs.jmedchem.7b01215

Reference yield:

: 38235-71-1
3-hydrazinobenzoic acid

: 1196452-44-4
isobutyl 3-(5-((1R,2S)-2-amino-1-phenylpropoxy)-1H-indazol-1-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1.33 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 0.5 h / 160 °C

3.1: sodium carbonate / 1-methyl-pyrrolidin-2-one / 40 - 55 °C

4.1: dimethylaminoacetic acid; caesium carbonate; copper(l) iodide / 0.5 h / 110 °C

4.2: 19 h / 110 °C / Sealed tube

With copper(l) iodide; dimethylaminoacetic acid; potassium tert-butylate; sodium carbonate; caesium carbonate; In 1-methyl-pyrrolidin-2-one; 4.1: |Ullmann Condensation / 4.2: |Ullmann Condensation;
DOI:10.1021/acs.jmedchem.7b01215