trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

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Chemical Name:trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol
CAS No.:1413876-18-2
Molecular Formula:C₃₁H₃₇ClF₄N₄O₂Si
Molecular Weight:637.192
Hs Code.:

Synonyms:trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

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Chemical Property of trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

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Technology Process of trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

There total 11 articles about trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1413875-99-6
5-[1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-1H-pyrazol-4-yl]-3-{1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoro-2,2-bis(phenylsulfonyl)ethyl}-1H-pyrrolo[2,3-b]pyridine

: 1413876-18-2
trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

Guidance literature:: With methanol; disodium hydrogenphosphate; sodium amalgam; In tetrahydrofuran; at -78 ℃; for 9h; Inert atmosphere;

Reference yield:

: 1175275-29-2
4-iodo-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazole

: 1413876-18-2
trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / pyridinium p-toluenesulfonate / acetone / 16 h / 65 °C

2.1: ethanol; sodium tetrahydroborate / 2 h / 20 °C / Inert atmosphere

3.1: 1H-imidazole / dmap / dichloromethane / 0.33 h / 20 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 1.08 h / 0 °C / Inert atmosphere

4.2: 1 h / 20 °C

5.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

6.1: disodium hydrogenphosphate; sodium amalgam; methanol / tetrahydrofuran / 9 h / -78 °C / Inert atmosphere

With 1H-imidazole; methanol; potassium fluoride; sodium tetrahydroborate; disodium hydrogenphosphate; sodium amalgam; ethanol; water; isopropylmagnesium chloride; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; pyridinium p-toluenesulfonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1413876-18-2
trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dmap / dichloromethane / 0.33 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.08 h / 0 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

4.1: disodium hydrogenphosphate; sodium amalgam; methanol / tetrahydrofuran / 9 h / -78 °C / Inert atmosphere

With 1H-imidazole; methanol; potassium fluoride; disodium hydrogenphosphate; sodium amalgam; isopropylmagnesium chloride; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;