trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

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Chemical Name:trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol
CAS No.:1413875-95-2
Molecular Formula:C₂₅H₂₃ClF₄N₄O₂
Molecular Weight:522.93
Hs Code.:

Synonyms:trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

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Chemical Property of trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

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Technology Process of trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

There total 11 articles about trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1413876-18-2
trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

: 1413875-95-2
trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

Guidance literature:: trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol; With water; hydrogenchloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 ℃;

Reference yield:

: 1175275-29-2
4-iodo-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazole

: 1413875-95-2
trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: water / pyridinium p-toluenesulfonate / acetone / 16 h / 65 °C

2.1: ethanol; sodium tetrahydroborate / 2 h / 20 °C / Inert atmosphere

3.1: 1H-imidazole / dmap / dichloromethane / 0.33 h / 20 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 1.08 h / 0 °C / Inert atmosphere

4.2: 1 h / 20 °C

5.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

6.1: disodium hydrogenphosphate; sodium amalgam; methanol / tetrahydrofuran / 9 h / -78 °C / Inert atmosphere

7.1: water / hydrogenchloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

7.2: 0 °C

With 1H-imidazole; methanol; potassium fluoride; sodium tetrahydroborate; disodium hydrogenphosphate; sodium amalgam; ethanol; water; isopropylmagnesium chloride; hydrogenchloride; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; pyridinium p-toluenesulfonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone;

Reference yield:

: 23511-05-9
toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester

: 1413875-95-2
trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 100 °C

2.1: water / pyridinium p-toluenesulfonate / acetone / 16 h / 65 °C

3.1: ethanol; sodium tetrahydroborate / 2 h / 20 °C / Inert atmosphere

4.1: 1H-imidazole / dmap / dichloromethane / 0.33 h / 20 °C

5.1: isopropylmagnesium chloride / tetrahydrofuran / 1.08 h / 0 °C / Inert atmosphere

5.2: 1 h / 20 °C

6.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

7.1: disodium hydrogenphosphate; sodium amalgam; methanol / tetrahydrofuran / 9 h / -78 °C / Inert atmosphere

8.1: water / hydrogenchloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

8.2: 0 °C

With 1H-imidazole; methanol; potassium fluoride; sodium tetrahydroborate; disodium hydrogenphosphate; sodium amalgam; ethanol; water; isopropylmagnesium chloride; caesium carbonate; hydrogenchloride; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; pyridinium p-toluenesulfonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone;