(E)-(3,4-difluorophenyl)(5-{[7-(6-fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime

Base Information

Chemical Name:(E)-(3,4-difluorophenyl)(5-{[7-(6-fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime
CAS No.:1202177-48-7
Molecular Formula:C₂₇H₂₈F₃N₅O
Molecular Weight:495.547
Hs Code.:

Synonyms:(E)-(3,4-difluorophenyl)(5-{[7-(6-fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime

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Chemical Property of (E)-(3,4-difluorophenyl)(5-{[7-(6-fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime

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Technology Process of (E)-(3,4-difluorophenyl)(5-{[7-(6-fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime

There total 5 articles about (E)-(3,4-difluorophenyl)(5-{[7-(6-fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1137951-00-8
(6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate

: 1202179-07-4
2-(6-Fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]nonane

: 1202177-48-7
(E)-(3,4-difluorophenyl)(5-{[7-(6-fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 0.0833333h; Microwaves;

Reference yield:

: 766-11-0
5-bromo-2-fluoropyridine

: 1202177-48-7
(E)-(3,4-difluorophenyl)(5-{[7-(6-fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 0.5 h / 130 °C / Microwaves

2: hydrogen / 20% palladium hydroxide on carbon / methanol / 18 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 0.08 h / 120 °C / Microwaves

With hydrogen; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20% palladium hydroxide on carbon; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 885275-27-4
2-benzyl 2,7-diaza-spiro-[4.4]nonane

: 1202177-48-7
(E)-(3,4-difluorophenyl)(5-{[7-(6-fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 0.5 h / 130 °C / Microwaves

2: hydrogen / 20% palladium hydroxide on carbon / methanol / 18 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 0.08 h / 120 °C / Microwaves

With hydrogen; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20% palladium hydroxide on carbon; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In methanol; N,N-dimethyl-formamide; toluene;