(E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime

Base Information

• Chemical Name: (E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime
• CAS No.: 1017599-32-4
• Molecular Formula: C₁₅H₁₄F₂N₂O₂
• Molecular Weight: 292.285

Synonyms:(E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime

Chemical Property of (E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime

Chemical Property:

Purity/Quality:

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Technology Process of (E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime

There total 2 articles about (E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-methyl 6-((3,4-difluorophenyl)(ethoxyimino)methyl)nicotinate (1192036-03-5) → (E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime (1017599-32-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1016/j.bmcl.2009.07.132

Reference yield:

→ (E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime (1017599-32-4)

Guidance literature:

Reference yield:

(E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime (1017599-32-4) + methanesulfonyl chloride (124-63-0) → (6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate (1137951-00-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2009.07.132

upstream raw materials:

(E)-methyl 6-((3,4-difluorophenyl)(ethoxyimino)methyl)nicotinate

Downstream raw materials:

(6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate

(E)-(3,4-difluorophenyl){5-[(7-pyrazolo[1,5-b]pyridazin-3-yl-2,7-diazaspiro[4.4]non-2-yl)methyl]-2-pyridinyl}methanone O-ethyloxime

1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate

(E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime

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