1-[5-(4-{(S)-1-[(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-2-oxo-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

Base Information

Chemical Name:1-[5-(4-{(S)-1-[(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-2-oxo-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide
CAS No.:1352753-96-8
Molecular Formula:C₂₉H₃₇N₃O₄
Molecular Weight:491.63
Hs Code.:

1-[5-(4-{(S)-1-[(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-2-oxo-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

Synonyms:1-[5-(4-{(S)-1-[(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-2-oxo-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

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Chemical Property of 1-[5-(4-{(S)-1-[(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-2-oxo-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

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Technology Process of 1-[5-(4-{(S)-1-[(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-2-oxo-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

There total 12 articles about 1-[5-(4-{(S)-1-[(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-2-oxo-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1352753-97-9
1-(5-bromo-pyridin-2-yl)-cyclopropanecarboxylic acid amide

: 1352754-38-1
(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-3-{(S)-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-[1,3]oxazinan-2-one

: 1352753-96-8
1-[5-(4-{(S)-1-[(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-2-oxo-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 100 ℃; for 2h;

Reference yield:

: 5239-82-7
cyclopropylacetic acid

: 1352753-96-8
1-[5-(4-{(S)-1-[(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-2-oxo-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine; HATU / dichloromethane / 3 h / 0 - 20 °C

2.1: tetrahydrofuran / 6 h / -78 - 20 °C / Inert atmosphere

3.1: methanol / 0.17 h / 80 °C

4.1: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

7.1: lithium triethylborohydride / tetrahydrofuran / 4.5 h / 0 - 20 °C

7.2: 0 °C

8.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 85 °C / Inert atmosphere

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 2 h / 100 °C

With potassium acetate; lithium triethylborohydride; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 1352754-35-8
1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol

: 1352753-96-8
1-[5-(4-{(S)-1-[(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-2-oxo-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

3.1: lithium triethylborohydride / tetrahydrofuran / 4.5 h / 0 - 20 °C

3.2: 0 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 85 °C / Inert atmosphere

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 2 h / 100 °C

With potassium acetate; lithium triethylborohydride; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;