ETHYL (4-NITROPHENYLAMINO) OXOACETATE

Base Information

• Chemical Name: ETHYL (4-NITROPHENYLAMINO) OXOACETATE
• CAS No.: 5416-11-5
• Molecular Formula: C10H10N2O5
• Molecular Weight: 238.2
• Hs Code.: 2924299090
• Mol file: 5416-11-5.mol

Synonyms:Ethyl (4-Nitrophenylamino) Oxoacetate;ethyl 2-[(p-nitrophenyl)amino]-2-oxoacetate;ethyl N-(4-nitrophenyl)oxamate;ethyl N-p-nitrophenyloxamate;ethyl 2-oxo-2-(p-nitrophenylamino)acetate;ethyl 4'-nitrooxanilate;ethyl 2-[(4-nitrophenyl)amino]-2-oxoacetate;

Chemical Property of ETHYL (4-NITROPHENYLAMINO) OXOACETATE

Chemical Property:

• Melting Point: 172-173°C
• PSA: 101.22000
• Density: 1.394g/cm³
• LogP: 1.69260
• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

99%min ^*data from raw suppliers

Ethyl(4-Nitrophenylamino)Oxoacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl (4-Nitrophenylamino) Oxoacetate (cas# 5416-11-5) is a compound useful in organic synthesis.

Technology Process of ETHYL (4-NITROPHENYLAMINO) OXOACETATE

There total 9 articles about ETHYL (4-NITROPHENYLAMINO) OXOACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Ethyl oxalyl chloride (4755-77-5) + 4-nitro-aniline (100-01-6,104810-17-5) → ethyl N-(4-nitrophenyl)oxamate (5416-11-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1002/ejoc.200300625

Reference yield: 84.0%

4-nitro-aniline (100-01-6,104810-17-5) + oxalic acid diethyl ester (95-92-1) → ethyl N-(4-nitrophenyl)oxamate (5416-11-5)

Guidance literature:

In xylene; for 2h; Heating;

DOI:10.1021/jf025870+ DOI:10.1021/jf052435h

Reference yield: 66.8%

ethyl 2-diazo-3-oxobutanoate (2009-97-4) + 4-nitro-aniline (100-01-6,104810-17-5) → ethyl N-(4-nitrophenyl)oxamate (5416-11-5)

Guidance literature:

With dirhodium tetraacetate; oxygen; In benzene; for 1h; Reflux;

DOI:10.1002/hlca.201200603

upstream raw materials:

Ethyl oxanilate

4-nitro-aniline

oxalic acid diethyl ester

Ethyl oxalyl chloride

Downstream raw materials:

N-(4-dimethylamino-phenyl)-N'-(4-nitro-phenyl)-oxalamide

N-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-N'-(4-nitro-phenyl)-oxalamide

1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid 4-nitro-anilide

N'-<4-Diaethylamino-1-methyl-butyl>-N-<4-nitro-phenyl>-oxamid

Refernces

• 1、 Zhu, Xiao-He,Zhang, Xin,Xin, Hong-Xing,Yan, Hong. "A transformation of N-alkylated anilines to N-aryloxamates". . p. 1542 - 1547. Retrieved 2013/09/02.
• 2、 -. "2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS". Page/Page column 132. . Retrieved 2008/12/05.