(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)ethyl pivalate

Base Information

Chemical Name:(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)ethyl pivalate
CAS No.:1354188-15-0
Molecular Formula:C₂₇H₃₂ClNO₄
Molecular Weight:470.008
Hs Code.:

Synonyms:(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)ethyl pivalate

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Chemical Property of (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)ethyl pivalate

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Technology Process of (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)ethyl pivalate

There total 13 articles about (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)ethyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354188-13-8
(S)-2-(5-bromo-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyethyl pivalate

: 1679-18-1
4-Chlorophenylboronic acid

: 1354188-15-0
(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)ethyl pivalate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 100 ℃; for 1.5h;

Reference yield:

: 50741-92-9
2-methyl-4-nitroanisole

: 1354188-15-0
(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)ethyl pivalate

Guidance literature:: Multi-step reaction with 12 steps

1.1: tin(II) chloride dihdyrate / triphenylphosphine; rhodium(III) chloride hydrate / isopropyl alcohol; 1,4-dioxane; water / 20 h / 180 °C / Inert atmosphere

2.1: N-Bromosuccinimide; sulfuric acid / 3.5 h / 15 °C

2.2: pH 10 / Cooling with ice

3.1: boron tribromide / dichloromethane / 3 h

3.2: 0.33 h / 0 °C

4.1: pyridine / dichloromethane / 2 h / -30 - 0 °C

5.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

6.1: hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 48 h / 0 °C

7.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

8.1: perchloric acid / 2 h / 25 °C

9.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h

10.1: 10 h / 140 °C

11.1: methylamine / ethanol; water / 1.33 h / 78 °C

12.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.5 h / 100 °C

With pyridine; N-Bromosuccinimide; perchloric acid; tin(II) chloride dihdyrate; hydroquinine 1,4-phthalazinediyl diether; sulfuric acid; boron tribromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; methylamine; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; rhodium(III) chloride hydrate; triphenylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;

Reference yield:

: 467219-83-6
6-methoxy-7-methylquinoline

: 1354188-15-0
(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)ethyl pivalate

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-Bromosuccinimide; sulfuric acid / 3.5 h / 15 °C

1.2: pH 10 / Cooling with ice

2.1: boron tribromide / dichloromethane / 3 h

2.2: 0.33 h / 0 °C

3.1: pyridine / dichloromethane / 2 h / -30 - 0 °C

4.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

5.1: hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 48 h / 0 °C

6.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

7.1: perchloric acid / 2 h / 25 °C

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h

9.1: 10 h / 140 °C

10.1: methylamine / ethanol; water / 1.33 h / 78 °C

11.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.5 h / 100 °C

With pyridine; N-Bromosuccinimide; perchloric acid; hydroquinine 1,4-phthalazinediyl diether; sulfuric acid; boron tribromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; methylamine; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;