N-(3-fluoro-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-8-yloxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-(3-fluoro-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-8-yloxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide
CAS No.:1528546-96-4
Molecular Formula:C₂₅H₁₆F₂N₄O₅
Molecular Weight:490.423
Hs Code.:

Synonyms:N-(3-fluoro-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-8-yloxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

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Chemical Property of N-(3-fluoro-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-8-yloxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

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Technology Process of N-(3-fluoro-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-8-yloxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

There total 5 articles about N-(3-fluoro-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-8-yloxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1052114-81-4
5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridin-3-ylcarboxylic acid

: 1528549-10-1
C₁₃H₁₀FN₃O₃

: 1528546-96-4
N-(3-fluoro-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-8-yloxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Guidance literature:: 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridin-3-ylcarboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 ℃; for 0.25h;

C₁₃H₁₀FN₃O₃; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: ethyl 5-(dimethylamino)-2-[(dimethylamino)methylidene]-4-(4-fluorophenyl)-3-oxopent-4-enoate

: 1528546-96-4
N-(3-fluoro-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-8-yloxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride / ethanol / 2 h / Reflux

2.1: sodium hydroxide / ethanol / 2 h / 65 °C

3.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C

3.2: 4 h / 20 °C

With ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In ethanol; dichloromethane;

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 1528546-96-4
N-(3-fluoro-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-8-yloxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 2.5 h / 0 °C

2.1: ethyl [2]alcohol / 87 °C

2.2: 3 h / 110 °C

3.1: ammonium chloride / ethanol / 2 h / Reflux

4.1: sodium hydroxide / ethanol / 2 h / 65 °C

5.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C

5.2: 4 h / 20 °C

With pyridine; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In ethanol; dichloromethane; ethyl [2]alcohol;