1-(2-aminophenyl)-4-(4-fluorophenyl)-3,3-dimethyl-2,3-dihydro-1H-indol-7-ol

Base Information

Chemical Name:1-(2-aminophenyl)-4-(4-fluorophenyl)-3,3-dimethyl-2,3-dihydro-1H-indol-7-ol
CAS No.:1617505-02-8
Molecular Formula:C₂₂H₂₁FN₂O
Molecular Weight:348.42
Hs Code.:

Synonyms:1-(2-aminophenyl)-4-(4-fluorophenyl)-3,3-dimethyl-2,3-dihydro-1H-indol-7-ol

Suppliers and Price of 1-(2-aminophenyl)-4-(4-fluorophenyl)-3,3-dimethyl-2,3-dihydro-1H-indol-7-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2-aminophenyl)-4-(4-fluorophenyl)-3,3-dimethyl-2,3-dihydro-1H-indol-7-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2-aminophenyl)-4-(4-fluorophenyl)-3,3-dimethyl-2,3-dihydro-1H-indol-7-ol

There total 6 articles about 1-(2-aminophenyl)-4-(4-fluorophenyl)-3,3-dimethyl-2,3-dihydro-1H-indol-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1617505-01-7
2-[4-(4-fluorophenyl)-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]aniline

: 1617505-02-8
1-(2-aminophenyl)-4-(4-fluorophenyl)-3,3-dimethyl-2,3-dihydro-1H-indol-7-ol

Guidance literature:: 2-[4-(4-fluorophenyl)-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]aniline; With boron trichloride; tetra-(n-butyl)ammonium iodide; In n-heptane; dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With water; In methanol; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm5006226

Reference yield:

: 1555701-57-9
4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

: 1617505-02-8
1-(2-aminophenyl)-4-(4-fluorophenyl)-3,3-dimethyl-2,3-dihydro-1H-indol-7-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 50 h / 100 °C / Inert atmosphere; Sealed tube

2.1: zinc; ammonium chloride / methanol; ethyl acetate / 1 h / 20 °C / Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane; n-heptane / -78 - 20 °C / Inert atmosphere

3.2: 0.5 h / 0 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium carbonate; ammonium chloride; zinc; In methanol; n-heptane; dichloromethane; ethyl acetate;
DOI:10.1021/jm5006226

Reference yield:

: 6358-77-6
5-bromo-2-methoxyaniline

: 1617505-02-8
1-(2-aminophenyl)-4-(4-fluorophenyl)-3,3-dimethyl-2,3-dihydro-1H-indol-7-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / water / -10 °C / Inert atmosphere

2.1: sulfuric acid / ethanol / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 0.75 h / 0 - 20 °C / Inert atmosphere

3.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 50 h / 100 °C / Inert atmosphere; Sealed tube

5.1: zinc; ammonium chloride / methanol; ethyl acetate / 1 h / 20 °C / Inert atmosphere

6.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane; n-heptane / -78 - 20 °C / Inert atmosphere

6.2: 0.5 h / 0 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium carbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; sodium nitrite; In methanol; ethanol; n-heptane; dichloromethane; water; ethyl acetate; toluene; 2.1: |Fischer Indole Synthesis;
DOI:10.1021/jm5006226