Technology Process of 4-(4-fluorophenyl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole
There total 4 articles about 4-(4-fluorophenyl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
at 100 ℃;
for 50h;
Inert atmosphere;
Sealed tube;
DOI:10.1021/jm5006226
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; sodium nitrite / water / -10 °C / Inert atmosphere
2.1: sulfuric acid / ethanol / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 0.75 h / 0 - 20 °C / Inert atmosphere
3.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube
4.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 50 h / 100 °C / Inert atmosphere; Sealed tube
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0); sulfuric acid; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium nitrite;
In
ethanol; water; toluene;
2.1: |Fischer Indole Synthesis;
DOI:10.1021/jm5006226
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / ethanol / 2 h / 0 - 20 °C / Inert atmosphere
1.2: 0.75 h / 0 - 20 °C / Inert atmosphere
2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube
3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 50 h / 100 °C / Inert atmosphere; Sealed tube
With
tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0); sulfuric acid; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
ethanol; toluene;
1.1: |Fischer Indole Synthesis;
DOI:10.1021/jm5006226
