ethyl 2,2-difluoro-2-[1-(phenylsulfonyl)-3-indolyl]acetate

Base Information

• Chemical Name: ethyl 2,2-difluoro-2-[1-(phenylsulfonyl)-3-indolyl]acetate
• CAS No.: 294182-01-7
• Molecular Formula: C₁₈H₁₅F₂NO₄S
• Molecular Weight: 379.384
• Mol file: 294182-01-7.mol

Synonyms:ethyl 2,2-difluoro-2-[1-(phenylsulfonyl)-3-indolyl]acetate

Chemical Property of ethyl 2,2-difluoro-2-[1-(phenylsulfonyl)-3-indolyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2,2-difluoro-2-[1-(phenylsulfonyl)-3-indolyl]acetate

There total 1 articles about ethyl 2,2-difluoro-2-[1-(phenylsulfonyl)-3-indolyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.6%

Ethyl bromodifluoroacetate (667-27-6) + 3-iodo-1-phenylsulfonyl-1H-indole (80360-14-1) → ethyl 2,2-difluoro-2-[1-(phenylsulfonyl)-3-indolyl]acetate (294182-01-7)

Guidance literature:

Ethyl bromodifluoroacetate; With copper; In dimethyl sulfoxide; at 20 ℃; for 1h;

3-iodo-1-phenylsulfonyl-1H-indole; In dimethyl sulfoxide; at 20 ℃; for 15h;

DOI:10.1248/cpb.48.982

Reference yield: 84.8%

2,4-difluorobromobenzene (348-57-2) + ethyl 2,2-difluoro-2-[1-(phenylsulfonyl)-3-indolyl]acetate (294182-01-7) → 2,2-difluoro-1-(2,4-difluorophenyl)-2-[1-(phenylsulfonyl)-3-indolyl]ethanone (294182-12-0)

Guidance literature:

2,4-difluorobromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

ethyl 2,2-difluoro-2-[1-(phenylsulfonyl)-3-indolyl]acetate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

DOI:10.1248/cpb.48.982

Reference yield:

methanol (67-56-1) + ethyl 2,2-difluoro-2-[1-(phenylsulfonyl)-3-indolyl]acetate (294182-01-7) → C17H15F2NO4S

Guidance literature:

With sodium tetrahydroborate; at -50 ℃; for 1h;

DOI:10.1016/j.tet.2007.12.002

upstream raw materials:

Ethyl bromodifluoroacetate

3-iodo-1-phenylsulfonyl-1H-indole

Downstream raw materials:

2,2-difluoro-1-(2,4-difluorophenyl)-2-[1-(phenylsulfonyl)-3-indolyl]ethanone