3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]-N-methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide trifluoroacetate

Base Information

Chemical Name:3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]-N-methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide trifluoroacetate
CAS No.:1445982-24-0
Molecular Formula:C₂HF₃O₂*C₃₂H₄₁Cl₂N₃O₈
Molecular Weight:780.623
Hs Code.:

3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]-N-methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide trifluoroacetate

Synonyms:3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]-N-methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide trifluoroacetate

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Chemical Property of 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]-N-methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide trifluoroacetate

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Technology Process of 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]-N-methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide trifluoroacetate

There total 15 articles about 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]-N-methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1445985-39-6
3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid

: 6284-40-8,97780-33-1
1-deoxy-1-(methylamino)-D-glucitol

: 76-05-1
trifluoroacetic acid

: 1445982-24-0
3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]-N-methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide trifluoroacetate

Guidance literature:: 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid; 1-deoxy-1-(methylamino)-D-glucitol; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1124-05-6
1,4-dichloro-2,5-dimethylbenzene

: 1445982-24-0
3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]-N-methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1: chromium(VI) oxide; sulfuric acid; acetic anhydride; acetic acid / 6 h / 20 °C

2: sodium hydroxide / dichloromethane; water / 1 h / 0 °C

3: sodium tetrahydroborate / methanol / 1 h / 20 °C

4: rhodium contaminated with carbon; hydrogen / ethyl acetate / 20 °C

5: N-Bromosuccinimide; triphenylphosphine / tetrahydrofuran; dichloromethane / 2 h / 20 °C

6: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 30 °C

7: trimethylsilyl bromide / dichloromethane / 2 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With chromium(VI) oxide; sodium tetrahydroborate; N-Bromosuccinimide; trimethylsilyl bromide; sulfuric acid; rhodium contaminated with carbon; hydrogen; acetic anhydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445982-24-0
3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]-N-methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 30 °C

5: trimethylsilyl bromide / dichloromethane / 2 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With borane-THF; trimethylsilyl bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;