3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid

Base Information

Chemical Name:3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid
CAS No.:1445985-39-6
Molecular Formula:C₂₅H₂₆Cl₂N₂O₄
Molecular Weight:489.398
Hs Code.:

Synonyms:3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid

Suppliers and Price of 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid

There total 15 articles about 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1445985-38-5
tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propatioate

: 1445985-39-6
3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1124-05-6
1,4-dichloro-2,5-dimethylbenzene

: 1445985-39-6
3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: chromium(VI) oxide; sulfuric acid; acetic anhydride; acetic acid / 6 h / 20 °C

2: sodium hydroxide / dichloromethane; water / 1 h / 0 °C

3: sodium tetrahydroborate / methanol / 1 h / 20 °C

4: rhodium contaminated with carbon; hydrogen / ethyl acetate / 20 °C

5: N-Bromosuccinimide; triphenylphosphine / tetrahydrofuran; dichloromethane / 2 h / 20 °C

6: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 30 °C

7: trimethylsilyl bromide / dichloromethane / 2 h / 20 °C

With chromium(VI) oxide; sodium tetrahydroborate; N-Bromosuccinimide; trimethylsilyl bromide; sulfuric acid; rhodium contaminated with carbon; hydrogen; acetic anhydride; potassium carbonate; acetic acid; triphenylphosphine; potassium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445985-39-6
3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropoxy]methyl)phenyl]propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 30 °C

5: trimethylsilyl bromide / dichloromethane / 2 h / 20 °C

With borane-THF; trimethylsilyl bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;