4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-ol

Base Information

• Chemical Name: 4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-ol
• CAS No.: 1271726-27-2
• Molecular Formula: C₂₈H₃₀N₂O₅S₂
• Molecular Weight: 538.689

Synonyms:4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-ol

Chemical Property of 4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-ol

Chemical Property:

Purity/Quality:

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Technology Process of 4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-ol

There total 4 articles about 4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-one (1271726-26-1) → 4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-ol (1271726-27-2)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.3987/COM-10-S(E)5

Reference yield:

1-benzenesulfonyl-pyrrolidin-2-one (88000-68-4) → 4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-ol (1271726-27-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -70 - 0 °C / Inert atmosphere

1.2: -70 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; sodium hydride; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; mineral oil;

DOI:10.3987/COM-10-S(E)5

Reference yield:

N-{4-[1-(benzenesulfonyl)-1H-indol-2-yl]-4-oxobutyl}benzenesulfonamide (1271726-25-0) → 4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-ol (1271726-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium hydride; In ethanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.3987/COM-10-S(E)5

upstream raw materials:

N-{4-[1-(benzenesulfonyl)-1H-indol-2-yl]-4-oxobutyl}benzenesulfonamide

4-(N-(E-but-2-en-1-yl)phenylsulfonylamido)-1-(1-phenylsulfonylindol-2-yl)butan-1-one

1-benzenesulfonyl-pyrrolidin-2-one

benzenesulfonyl chloride

Downstream raw materials:

2-(E-but-2-en-1-yl)-1,2,3,4,5,7-hexahydro-7-phenylsulfonyl-6H-azocino[4,3-b]indol-6-one

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