C₂₈H₄₀O₅Si

Base Information

• Chemical Name: C₂₈H₄₀O₅Si
• CAS No.: 1359984-31-8
• Molecular Formula: C₂₈H₄₀O₅Si
• Molecular Weight: 484.708
• Mol file: 1359984-31-8.mol

Synonyms:C₂₈H₄₀O₅Si

Chemical Property of C₂₈H₄₀O₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₄₀O₅Si

There total 5 articles about C₂₈H₄₀O₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2R,3S,4R)-ethyl 4-(tert-butyldiphenylsilyloxy)-2,3-dihydroxyheptanoate (1359984-30-7) + 2,2-dimethoxy-propane (77-76-9) → C28H40O5Si (1359984-31-8)

Guidance literature:

With CSA;

DOI:10.1016/j.tetlet.2011.12.119

Reference yield:

(R,Z)-ethyl 4-(tert-butyldiphenylsilyloxy)hept-2-enoate (1359984-28-3) → C28H40O5Si (1359984-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: AD-mix β; methanesulfonamide; water / tert-butyl alcohol / 24 h / 20 °C

2: CSA

With methanesulfonamide; AD-mix β; water; In tert-butyl alcohol; 1: Sharpless dihydroxylation;

DOI:10.1016/j.tetlet.2011.12.119

Reference yield:

C21H27NOSi (1359984-40-9) → C28H40O5Si (1359984-31-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / dichloromethane / -78 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 0 °C

3.1: AD-mix β; methanesulfonamide; water / tert-butyl alcohol / 24 h / 20 °C

4.1: CSA

With methanesulfonamide; AD-mix β; water; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; mineral oil; tert-butyl alcohol; 2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination / 3.1: Sharpless dihydroxylation;

DOI:10.1016/j.tetlet.2011.12.119

upstream raw materials:

(R,Z)-ethyl 4-(tert-butyldiphenylsilyloxy)hept-2-enoate

(2R,3S,4R)-ethyl 4-(tert-butyldiphenylsilyloxy)-2,3-dihydroxyheptanoate

2,2-dimethoxy-propane

C₂₁H₂₇NOSi

Downstream raw materials:

C₂₆H₃₆O₄Si

C₂₇H₃₈O₃Si

(E)-3-((4S,5S)-5-((R)-1-(tert-butyldiphenylsilyloxy)butyl)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylaldehyde

(R,E)-1-((4S,5S)-5-((R)-1-(tert-butyldiphenylsilyloxy)butyl)-2,2-dimethyl-1,3-dioxolan-4-yl)hexa-1,5-dien-3-ol