6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one

Base Information

Chemical Name:6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one
CAS No.:889359-32-4
Molecular Formula:C₂₆H₂₈F₃N₃O₂Si
Molecular Weight:499.608
Hs Code.:

Synonyms:6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one

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Chemical Property of 6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one

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Technology Process of 6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one

There total 7 articles about 6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-azido-4-bromo-benzoyl chloride

: 889359-32-4
6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: DMAP / CH₂Cl₂

2.1: 85 percent / SOCl₂ / 24 h / Heating

3.1: 86 percent / KOH / methanol / 0.25 h / 150 °C / microwave irradiation

4.1: NaH / tetrahydrofuran / 20 h / 20 °C

4.2: tetrahydrofuran

5.1: bis(pinacolato)diborane; Pd(dppf)Cl₂; KOAc / dioxane / 18 h / Heating

5.2: Pd(dppf)Cl₂; aq. Na₂CO₃ / 18 h / Heating

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide; thionyl chloride; potassium acetate; sodium hydride; bis(pinacol)diborane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.03.004

Reference yield:

: 852620-79-2
2-azido-4-bromobenzoic acid

: 889359-32-4
6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: SOCl₂ / Heating

2.1: DMAP / CH₂Cl₂

3.1: 85 percent / SOCl₂ / 24 h / Heating

4.1: 86 percent / KOH / methanol / 0.25 h / 150 °C / microwave irradiation

5.1: NaH / tetrahydrofuran / 20 h / 20 °C

5.2: tetrahydrofuran

6.1: bis(pinacolato)diborane; Pd(dppf)Cl₂; KOAc / dioxane / 18 h / Heating

6.2: Pd(dppf)Cl₂; aq. Na₂CO₃ / 18 h / Heating

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide; thionyl chloride; potassium acetate; sodium hydride; bis(pinacol)diborane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.03.004

Reference yield:

: 852620-82-7
1,2-dihydro-6-bromo-2-(4-trifluoromethylphenyl)-3H-indazol-3-one

: 889359-32-4
6-(3-methyl-pyridin-2-yl)-2-(4-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-indazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 20 h / 20 °C

1.2: tetrahydrofuran

2.1: bis(pinacolato)diborane; Pd(dppf)Cl₂; KOAc / dioxane / 18 h / Heating

2.2: Pd(dppf)Cl₂; aq. Na₂CO₃ / 18 h / Heating

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium hydride; bis(pinacol)diborane; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmcl.2006.03.004