6-Bromo-1,2-dihydro-2-(4-trifluoromethylphenyl)-1-(2-trimethylsilylethoxymethyl)-3H-indazol-3-one

Base Information

Chemical Name:6-Bromo-1,2-dihydro-2-(4-trifluoromethylphenyl)-1-(2-trimethylsilylethoxymethyl)-3H-indazol-3-one
CAS No.:852620-83-8
Molecular Formula:C₂₀H₂₂BrF₃N₂O₂Si
Molecular Weight:487.392
Hs Code.:

Synonyms:6-Bromo-1,2-dihydro-2-(4-trifluoromethylphenyl)-1-(2-trimethylsilylethoxymethyl)-3H-indazol-3-one

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Chemical Property of 6-Bromo-1,2-dihydro-2-(4-trifluoromethylphenyl)-1-(2-trimethylsilylethoxymethyl)-3H-indazol-3-one

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Technology Process of 6-Bromo-1,2-dihydro-2-(4-trifluoromethylphenyl)-1-(2-trimethylsilylethoxymethyl)-3H-indazol-3-one

There total 6 articles about 6-Bromo-1,2-dihydro-2-(4-trifluoromethylphenyl)-1-(2-trimethylsilylethoxymethyl)-3H-indazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852620-82-7
1,2-dihydro-6-bromo-2-(4-trifluoromethylphenyl)-3H-indazol-3-one

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 852620-83-8
6-Bromo-1,2-dihydro-2-(4-trifluoromethylphenyl)-1-(2-trimethylsilylethoxymethyl)-3H-indazol-3-one

Guidance literature:: 1,2-dihydro-6-bromo-2-(4-trifluoromethylphenyl)-3H-indazol-3-one; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 20h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2006.03.004

Reference yield:

: 2-azido-4-bromo-benzoyl chloride

: 852620-83-8
6-Bromo-1,2-dihydro-2-(4-trifluoromethylphenyl)-1-(2-trimethylsilylethoxymethyl)-3H-indazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: DMAP / CH₂Cl₂

2.1: 85 percent / SOCl₂ / 24 h / Heating

3.1: 86 percent / KOH / methanol / 0.25 h / 150 °C / microwave irradiation

4.1: NaH / tetrahydrofuran / 20 h / 20 °C

4.2: tetrahydrofuran

With dmap; potassium hydroxide; thionyl chloride; sodium hydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.03.004

Reference yield:

: 852620-79-2
2-azido-4-bromobenzoic acid

: 852620-83-8
6-Bromo-1,2-dihydro-2-(4-trifluoromethylphenyl)-1-(2-trimethylsilylethoxymethyl)-3H-indazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: SOCl₂ / Heating

2.1: DMAP / CH₂Cl₂

3.1: 85 percent / SOCl₂ / 24 h / Heating

4.1: 86 percent / KOH / methanol / 0.25 h / 150 °C / microwave irradiation

5.1: NaH / tetrahydrofuran / 20 h / 20 °C

5.2: tetrahydrofuran

With dmap; potassium hydroxide; thionyl chloride; sodium hydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.03.004