7-Methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester

Base Information

• Chemical Name: 7-Methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester
• CAS No.: 82140-67-8
• Molecular Formula: C₁₆H₁₃N₃O₃S
• Molecular Weight: 327.364
• Mol file: 82140-67-8.mol

Synonyms:7-Methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester

Chemical Property of 7-Methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester

There total 4 articles about 7-Methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

dimethyl 2-chloro-6-methylpyridine-3,4-dicarboxylate (82140-59-8) + monophenylthiourea (103-85-5) → 7-Methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester (82140-67-8)

Guidance literature:

With hydrogenchloride; In methanol; for 10h; Heating;

Reference yield:

2-hydroxy-6-methylpyridine-3,4-dicarboxylic acid (2860-55-1) → 7-Methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester (82140-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) POCl₃, PCl₅ / 1.) reflux, 2 h, 2.) reflux, 2 h

2: 20 percent / hydrogen chloride / methanol / 10 h / Heating

With hydrogenchloride; phosphorus pentachloride; trichlorophosphate; In methanol;

Reference yield:

2-Chloro-6-methyl-pyridine-3,4-dicarboxylic acid 4-methyl ester (82140-73-6) → 7-Methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester (82140-67-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 1.) room temperature, 1 h, 2.) reflux 2 h

2: benzene / 1 h / Ambient temperature

3: 20 percent / hydrogen chloride / methanol / 10 h / Heating

With hydrogenchloride; thionyl chloride; In methanol; benzene;

upstream raw materials:

dimethyl 2-chloro-6-methylpyridine-3,4-dicarboxylate

monophenylthiourea

2-hydroxy-6-methylpyridine-3,4-dicarboxylic acid

2-Chloro-6-methyl-pyridine-3,4-dicarboxylic acid 4-methyl ester

Downstream raw materials:

7-methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid