(1R,2S)-3--1,2-epoxy-1-phenylpropane

Base Information

Chemical Name:(1R,2S)-3--1,2-epoxy-1-phenylpropane
CAS No.:223394-13-6
Molecular Formula:C₂₁H₂₃NO₂
Molecular Weight:321.419
Hs Code.:

(1R,2S)-3-<N-(benzoyl)piperidin-4-yl>-1,2-epoxy-1-phenylpropane

Synonyms:(1R,2S)-3--1,2-epoxy-1-phenylpropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-3--1,2-epoxy-1-phenylpropane

Chemical Property:

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Technology Process of (1R,2S)-3--1,2-epoxy-1-phenylpropane

There total 12 articles about (1R,2S)-3--1,2-epoxy-1-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5344-27-4
4-(2-hydroxyethyl)pyridine

: 223394-13-6
(1R,2S)-3--1,2-epoxy-1-phenylpropane

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / H₂, conc. HCl / Pt/C / H₂O / 264 h / Ambient temperature

2: 98 percent / 4M NaOH / Ambient temperature

3: (COCl)2, DMSO, Et₃N / tetrahydrofuran / 0.5 h / -35 - 20 °C

4: 1.) nBuLi / 1.) THF, hexane, room temperature, 30 min, 2.) -78 deg C -> room temperature, 1 h

5: I₂ / CHCl₃ / 192 h / Irradiation

6: 72 percent / Ad-mix-β, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 1.) 0 deg C, 7 h, 2.) room temperature, 17 h

7: 1.), 2.) NaH / 1.) Py, -20 deg C, 24 h, 2.) THF, room temperature, 3 days

With hydrogenchloride; sodium hydroxide; n-butyllithium; oxalyl dichloride; methanesulfonamide; AD-mix-β; hydrogen; iodine; sodium hydride; dimethyl sulfoxide; triethylamine; platinum on activated charcoal; In tetrahydrofuran; chloroform; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00050-2

Reference yield:

: 152902-80-2
(4-(2-hydroxyethyl)piperidin-1-yl)(phenyl)methanone

: 223394-13-6
(1R,2S)-3--1,2-epoxy-1-phenylpropane

Guidance literature:: Multi-step reaction with 5 steps

1: (COCl)2, DMSO, Et₃N / tetrahydrofuran / 0.5 h / -35 - 20 °C

2: 1.) nBuLi / 1.) THF, hexane, room temperature, 30 min, 2.) -78 deg C -> room temperature, 1 h

3: I₂ / CHCl₃ / 192 h / Irradiation

4: 72 percent / Ad-mix-β, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 1.) 0 deg C, 7 h, 2.) room temperature, 17 h

5: 1.), 2.) NaH / 1.) Py, -20 deg C, 24 h, 2.) THF, room temperature, 3 days

With n-butyllithium; oxalyl dichloride; methanesulfonamide; AD-mix-β; iodine; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; chloroform; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00050-2

Reference yield:

: 223393-97-3
2-ethanal

: 223394-13-6
(1R,2S)-3--1,2-epoxy-1-phenylpropane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) nBuLi / 1.) THF, hexane, room temperature, 30 min, 2.) -78 deg C -> room temperature, 1 h

2: I₂ / CHCl₃ / 192 h / Irradiation

3: 72 percent / Ad-mix-β, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 1.) 0 deg C, 7 h, 2.) room temperature, 17 h

4: 1.), 2.) NaH / 1.) Py, -20 deg C, 24 h, 2.) THF, room temperature, 3 days

With n-butyllithium; methanesulfonamide; AD-mix-β; iodine; sodium hydride; In chloroform; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00050-2