223393-97-3

Upstream product

• 98-88-4 benzoyl chloride 
• 28356-58-3 pyridine-4-acetic acid 
• 622-26-4 4-(2-Hydroxyethyl)piperidine 
• 5344-27-4 4-(2-hydroxyethyl)pyridine 
• 152902-80-2 (4-(2-hydroxyethyl)piperidin-1-yl)(phenyl)methanone 

Downstream Products

• 189109-40-8 E-3-(N-benzoylpiperidin-4-yl)-1-phenylprop-1-ene 
• 189177-06-8 (2R,1'S)-2-(1-hydroxy-1-phenyl)methyl-1-azabicyclo[2.2.2]octane 
• 189177-29-5 2-(1-hydroxy-1-phenyl)methyl-1-azabicyclo[2.2.2]octane 
• 223394-05-6 (1S,2S)-3--1,2-dihydroxy-1-(naphth-1-yl)propane 
• 223394-06-7 (1S,2S)-3--1,2-epoxy-1-(nahth-1-yl)propane 
• 223394-04-5 E-3--1-(naphth-1-yl)prop-1-ene 
• 223394-19-2 (2S,3S)-4--2,3-epoxy-1-methoxybutane 
• 223394-11-4 (1R,2R)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane 
• 189109-57-7 (1S,2S)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane 
• 223393-98-4 (1R,2R)-3--1,2-dihydroxy-1-phenylpropane 
• 189109-44-2 (1S,2S)-3--1,2-dihydroxy-1-phenylpropane 

Relevant academic research and scientific papers

Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C-H Functionalization

Reliable regio- and stereochemical techniques applicable to nonactivated aliphatic systems remain largely elusive due to the challenges of discriminating between multiple, relatively strong sp3 C-H bonds whose chemical behavior often differ onl

Asymmetric approaches to 2-hydroxymethylquinuclidine derivatives

Highly enantio- and diastereoselective routes to 2- hydroxymethylquinuclidines have been developed. Key steps involve the use of Sharpless dihydroxylation or Sharpless epoxidation to introduce the asymmetry with high stereocontrol, and formation of the quinuclidine ring systems via cyclisation of epoxy amines.

Enantio- and diastereoselective synthesis of all four possible stereoisomers of 2-(phenylhydroxymethyl)quinuclidine

An enantio- and diastereoselective synthesis of all four possible stereoisomers of 2-(phenylhydroxymethyl)quinuclidine is reported. Key steps involve the use of the Sharpless dihydroxylation protocol to induce asymmetry, and stereodivergent cyclisations of the resulting diol to form the quinuclidine ring.