di-tert-butyl 2-(4-aminophenyl)-2-methylmalonate hydrochloride

Base Information

Chemical Name:di-tert-butyl 2-(4-aminophenyl)-2-methylmalonate hydrochloride
CAS No.:1006950-22-6
Molecular Formula:C₁₈H₂₇NO₄
Molecular Weight:321.417
Hs Code.:

Synonyms:di-tert-butyl 2-(4-aminophenyl)-2-methylmalonate hydrochloride

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Chemical Property of di-tert-butyl 2-(4-aminophenyl)-2-methylmalonate hydrochloride

Chemical Property:

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Technology Process of di-tert-butyl 2-(4-aminophenyl)-2-methylmalonate hydrochloride

There total 5 articles about di-tert-butyl 2-(4-aminophenyl)-2-methylmalonate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1006899-48-4
di-tert-butyl 2-methyl-2-(4-nitrophenyl)malonate

: 1006950-22-6
di-tert-butyl 2-(4-aminophenyl)-2-methylmalonate hydrochloride

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In ethanol; for 0.5h; Reflux;

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 1006950-22-6
di-tert-butyl 2-(4-aminophenyl)-2-methylmalonate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Cooling with ice

1.2: 1.17 h / 20 - 120 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

With potassium tert-butylate; ammonium formate; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 278791-31-4
di-t-butyl 2-(4-nitrophenyl)malonate

: 1006950-22-6
di-tert-butyl 2-(4-aminophenyl)-2-methylmalonate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / Reflux

With ammonium formate; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; mineral oil;