7-chloro-2-[(E)-2-(3-{(S)-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]-1-trimethylsilanyloxypropyl}phenyl)vinyl]quinoline

Base Information

Chemical Name:7-chloro-2-[(E)-2-(3-{(S)-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]-1-trimethylsilanyloxypropyl}phenyl)vinyl]quinoline
CAS No.:1359172-74-9
Molecular Formula:C₃₅H₄₄ClNO₂Si₂
Molecular Weight:602.364
Hs Code.:

Synonyms:7-chloro-2-[(E)-2-(3-{(S)-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]-1-trimethylsilanyloxypropyl}phenyl)vinyl]quinoline

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Chemical Property of 7-chloro-2-[(E)-2-(3-{(S)-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]-1-trimethylsilanyloxypropyl}phenyl)vinyl]quinoline

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Technology Process of 7-chloro-2-[(E)-2-(3-{(S)-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]-1-trimethylsilanyloxypropyl}phenyl)vinyl]quinoline

There total 1 articles about 7-chloro-2-[(E)-2-(3-{(S)-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]-1-trimethylsilanyloxypropyl}phenyl)vinyl]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-77-4
chloro-trimethyl-silane

: 287930-77-2
(S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol

: 1359172-74-9
7-chloro-2-[(E)-2-(3-{(S)-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]-1-trimethylsilanyloxypropyl}phenyl)vinyl]quinoline

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 94.0%

: 1359172-74-9
7-chloro-2-[(E)-2-(3-{(S)-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]-1-trimethylsilanyloxypropyl}phenyl)vinyl]quinoline

: 1359172-54-5
(S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxy-ethyl)-phenyl]-propan-1-ol

Guidance literature:: With ammonia; In methanol; at 50 ℃; for 12h;

Reference yield:

: 1359172-74-9
7-chloro-2-[(E)-2-(3-{(S)-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]-1-trimethylsilanyloxypropyl}phenyl)vinyl]quinoline

: 577953-88-9
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / methanol / 12 h / 50 °C

2.1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C

3.1: 1-methyl-pyrrolidin-2-one / 0 - 20 °C / Inert atmosphere

4.1: sodium hydroxide; water / 2-methyltetrahydrofuran; methanol / 2 h / 70 - 80 °C / Inert atmosphere

4.2: 20 °C

With ammonia; water; triethylamine; sodium hydroxide; In 2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;