2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester
• CAS No.: 1037183-80-4
• Molecular Formula: C₁₄H₁₆IN₃O₂
• Molecular Weight: 385.204
• Mol file: 1037183-80-4.mol

Synonyms:2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester

Chemical Property of 2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester

There total 2 articles about 2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-bromo-1-(2-iodophenyl)ethanone (113258-84-7) + tert-butyl N-(diaminomethylidene)carbamate (219511-71-4) → 2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester (1037183-80-4)

Guidance literature:

With sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1021/jo800618q

Reference yield:

2-Iodobenzoic acid (88-67-5) → 2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester (1037183-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: diethyl ether; dichloromethane / 1 h / 0 °C

3: sodium iodide / N,N-dimethyl-formamide / 72 h / 20 °C

With oxalyl dichloride; sodium iodide; N,N-dimethyl-formamide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield: 75.0%

2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester (1037183-80-4) + di-tert-butyl dicarbonate (24424-99-5) → 2-tert-butoxycarbonylamino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester (1037183-83-7)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jo800618q

upstream raw materials:

2-bromo-1-(2-iodophenyl)ethanone

tert-butyl N-(diaminomethylidene)carbamate

2-Iodobenzoic acid

Downstream raw materials:

2-tert-butoxycarbonylamino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester