113258-84-7

Basic information

• Product Name: Ethanone, 2-broMo-1-(2-iodophenyl)-
• Synonyms: Ethanone, 2-broMo-1-(2-iodophenyl)-
• CAS NO: 113258-84-7
• Molecular Formula: C₈H₆BrIO
• Molecular Weight: 324.94111
• Mol File: 113258-84-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 162-164 °C(Press: 6 Torr)
• Appearance: /
• Density: 2.080±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethanone, 2-broMo-1-(2-iodophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-broMo-1-(2-iodophenyl)-(113258-84-7)
• EPA Substance Registry System: Ethanone, 2-broMo-1-(2-iodophenyl)-(113258-84-7)

Safety Data

• Hazardous Substances Data: 113258-84-7(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-bromo-1-(2-iodophenyl)- is a chemical compound with the molecular formula C8H6BrIO. It is classified as an organobromine compound and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Ethanone, 2-broMo-1-(2-iodophenyl)- is often used in the production of various drugs and can also be used as a reagent in organic chemical reactions. It is important to handle this chemical with care, as it can be hazardous to health and the environment if not properly managed.

Upstream product

• 551-93-9 2-aminoacetophenone 
• 88-67-5 2-Iodobenzoic acid 
• 186581-53-3 diazomethane 
• 2142-70-3 2-iodoacetophenone 
• 609-67-6 2-Iodobenzoyl chloride 
• 18282-40-1 1-ethyl-2-iodobenzene 

Downstream Products

• 1037183-80-4 2-amino-5-(2-iodophenyl)imidazole-1-carboxylic acid tert-butyl ester 
• 1509927-93-8 O-ethyl-S-[2-(2-iodophenyl)-2-oxoethyl] carbonodithioate 
• 452962-75-3 1-(2-iodophenyl)-2-phenoxyethanone 
• 452962-66-2 3-(2-iodophenyl)benzofuran 

Relevant articles and documents

N-Heterocyclic Iod(az)olium Salts – Potent Halogen-Bond Donors in Organocatalysis

This article describes the application of N-heterocyclic iod(az)olium salts (NHISs) as highly reactive organocatalysts. A variety of mono- and dicationic NHISs are described and utilized as potent XB-donors in halogen-bond catalysis. They were benchmarked in seven diverse test reactions in which the activation of carbon- and metal-chloride bonds as well as carbonyl and nitro groups was achieved. N-methylated dicationic NHISs rendered the highest reactivity in all investigated catalytic applications with reactivities even higher than all previously described monodentate XB-donors based on iodine(I) and (III) and the strong Lewis acid BF3.

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH)

Given the putative role of PHGDH in cancer, development of inhibitors is required to explore its function. In this context, we established and validated a straightforward enzymatic assay suitable for high-throughput screening and we identified inhibitors with similar chemical scaffolds. Through a convergent pharmacophore approach, we synthesized α-ketothioamides that exhibit interesting in vitro PHGDH inhibition and encouraging cellular results. These novel probes may be used to understand the emerging biology of this metabolic target.

FUSED-RING COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USES THEREOF

This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases.