<3(S,R),4(S,R)>-2-<<(tert-butyldimethylsilyl)oxy>imino>-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide

Base Information

Chemical Name:<3(S,R),4(S,R)>-2-<<(tert-butyldimethylsilyl)oxy>imino>-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide
CAS No.:131565-18-9
Molecular Formula:C₂₂H₃₈N₂O₄Si
Molecular Weight:422.64
Hs Code.:

Synonyms:<3(S,R),4(S,R)>-2-<<(tert-butyldimethylsilyl)oxy>imino>-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide

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Chemical Property of <3(S,R),4(S,R)>-2-<<(tert-butyldimethylsilyl)oxy>imino>-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide

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Technology Process of <3(S,R),4(S,R)>-2-<<(tert-butyldimethylsilyl)oxy>imino>-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide

There total 5 articles about <3(S,R),4(S,R)>-2-<<(tert-butyldimethylsilyl)oxy>imino>-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 88089-97-8
N-tert-butyl-2-<<(tert-butyldimethylsilyl)oxy>imino>butanamide

: 123-11-5
4-methoxy-benzaldehyde

: 131565-18-9
<3(S,R),4(S,R)>-2-<<(tert-butyldimethylsilyl)oxy>imino>-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1039/c39830000873

Reference yield: 62.0%

: 594-19-4
tert.-butyl lithium

: 88089-97-8
N-tert-butyl-2-<<(tert-butyldimethylsilyl)oxy>imino>butanamide

: 123-11-5
4-methoxy-benzaldehyde

: 131565-18-9
<3(S,R),4(S,R)>-2-<<(tert-butyldimethylsilyl)oxy>imino>-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; pentane; at -78 ℃; for 1.5h;
DOI:10.1021/jo00005a042

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 131565-18-9
<3(S,R),4(S,R)>-2-<<(tert-butyldimethylsilyl)oxy>imino>-4-hydroxy-4-(4-methoxyphenyl)-3-methyl-N-tert-butylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / imidazole / dimethylformamide

2: 74 percent / tBuLi, TMEDA / tetrahydrofuran / -78 °C

With 1H-imidazole; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c39830000873