(2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol

Base Information

Chemical Name:(2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol
CAS No.:957782-26-2
Molecular Formula:C₂₄H₄₄O₄Si
Molecular Weight:424.696
Hs Code.:

Synonyms:(2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol

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Chemical Property of (2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol

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Technology Process of (2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol

There total 5 articles about (2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 663942-91-4
(2S,3R,4R)-3,5-dihydroxy-2,4-dimethylpentyl acetate

: 957782-26-2
(2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 4 h

2: 72.0 mg / KOH; MeOH / CH₂Cl₂ / 20 °C

3: 90 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; methanol; potassium hydroxide; Dess-Martin periodane; toluene-4-sulfonic acid; In dichloromethane; 3: Dess-Martin oxidation;
DOI:10.1021/jo701524p

Reference yield:

: C₁₇H₂₄O₅

: 957782-26-2
(2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 72.0 mg / KOH; MeOH / CH₂Cl₂ / 20 °C

2: 90 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; methanol; potassium hydroxide; Dess-Martin periodane; In dichloromethane; 2: Dess-Martin oxidation;
DOI:10.1021/jo701524p

Reference yield:

: 957782-23-9
(S)-2-((2R,4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

: 957782-26-2
(2R,3R,4R,5R)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; Dess-Martin periodane; In dichloromethane; 1: Dess-Martin oxidation;
DOI:10.1021/jo701524p