ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

Base Information

Chemical Name:ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate
CAS No.:1268383-80-7
Molecular Formula:C₃₀H₂₄F₅N₅O₃
Molecular Weight:597.544
Hs Code.:

Synonyms:ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

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Chemical Property of ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

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Technology Process of ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

There total 6 articles about ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 64-17-5
ethanol

: 1268383-79-4
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

: 1268383-80-7
ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

Guidance literature:: With potassium carbonate; at 20 ℃; for 1h;

Reference yield:

: 39891-13-9
2-(6-chloropyridin-3-yl)acetic acid

: 1268383-80-7
ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 20 °C

2.1: cesium fluoride / 1,2-dimethoxyethane / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 21 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

5.1: potassium carbonate / 1 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; cesium fluoride; In methanol; tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

: 717106-69-9
methyl 2-(6-chloropyridin-3-yl)acetate

: 1268383-80-7
ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: cesium fluoride / 1,2-dimethoxyethane / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 21 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4.1: potassium carbonate / 1 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; cesium fluoride; In tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide;