N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

Base Information

Chemical Name:N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide
CAS No.:1351940-63-0
Molecular Formula:C₃₄H₃₃ClN₆O₄
Molecular Weight:625.127
Hs Code.:

Synonyms:N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

There total 15 articles about N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351940-61-8
N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(piperidin-4-ylidene)acetamide

: 74-88-4
methyl iodide

: 1351940-63-0
N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃;

Reference yield:

: 1351942-44-3
(E/Z)-ethyl 2-cyano-3-(4-nitro-3-(tetrahydrofuran-3-yl-oxy)-phenylamino)-acrylate

: 1351940-63-0
N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: biphenyl; diphenylether / 2 h / 256 °C / Inert atmosphere

2.1: trichlorophosphate / 2.5 h / 105 °C / Inert atmosphere

3.1: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

4.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

5.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.33 h / -5 °C

5.2: Cooling with ice

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: potassium carbonate / acetonitrile / 20 °C

With 4-methyl-morpholine; tin(II) chloride dihdyrate; pyridine hydrochloride; potassium carbonate; trifluoroacetic acid; trichlorophosphate; isobutyl chloroformate; In tetrahydrofuran; diphenylether; biphenyl; ethanol; dichloromethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 1351942-45-4
4-hydroxy-6-nitro-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

: 1351940-63-0
N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(1-methylpiperidin-4-ylidene)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 2.5 h / 105 °C / Inert atmosphere

2.1: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

3.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

4.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.33 h / -5 °C

4.2: Cooling with ice

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: potassium carbonate / acetonitrile / 20 °C

With 4-methyl-morpholine; tin(II) chloride dihdyrate; pyridine hydrochloride; potassium carbonate; trifluoroacetic acid; trichlorophosphate; isobutyl chloroformate; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; acetonitrile;