N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(piperidin-4-ylidene)acetamide

Base Information

Chemical Name:N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(piperidin-4-ylidene)acetamide
CAS No.:1351940-61-8
Molecular Formula:C₃₃H₃₁ClN₆O₄
Molecular Weight:611.1
Hs Code.:

Synonyms:N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(piperidin-4-ylidene)acetamide

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Chemical Property of N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(piperidin-4-ylidene)acetamide

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Technology Process of N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(piperidin-4-ylidene)acetamide

There total 15 articles about N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(piperidin-4-ylidene)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351940-60-7
tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate

: 1351940-61-8
N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(piperidin-4-ylidene)acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1351943-50-4
6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

: 1351940-61-8
N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(piperidin-4-ylidene)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.33 h / -5 °C

1.2: Cooling with ice

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With 4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1351942-44-3
(E/Z)-ethyl 2-cyano-3-(4-nitro-3-(tetrahydrofuran-3-yl-oxy)-phenylamino)-acrylate

: 1351940-61-8
N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)-2-(piperidin-4-ylidene)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: biphenyl; diphenylether / 2 h / 256 °C / Inert atmosphere

2.1: trichlorophosphate / 2.5 h / 105 °C / Inert atmosphere

3.1: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

4.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

5.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.33 h / -5 °C

5.2: Cooling with ice

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With 4-methyl-morpholine; tin(II) chloride dihdyrate; pyridine hydrochloride; trifluoroacetic acid; trichlorophosphate; isobutyl chloroformate; In tetrahydrofuran; diphenylether; biphenyl; ethanol; dichloromethane; isopropyl alcohol;