3-{[1-({[tert-butyl (dimethyl)silyl]oxy}methyl)cyclobutyl]oxy}-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Base Information

Chemical Name:3-{[1-({[tert-butyl (dimethyl)silyl]oxy}methyl)cyclobutyl]oxy}-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide
CAS No.:1310807-65-8
Molecular Formula:C₂₂H₃₃N₃O₄Si
Molecular Weight:431.607
Hs Code.:

Synonyms:3-{[1-({[tert-butyl (dimethyl)silyl]oxy}methyl)cyclobutyl]oxy}-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide

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Chemical Property of 3-{[1-({[tert-butyl (dimethyl)silyl]oxy}methyl)cyclobutyl]oxy}-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide

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Technology Process of 3-{[1-({[tert-butyl (dimethyl)silyl]oxy}methyl)cyclobutyl]oxy}-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide

There total 6 articles about 3-{[1-({[tert-butyl (dimethyl)silyl]oxy}methyl)cyclobutyl]oxy}-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310807-64-7
3-(benzyloxy)-5-{[1-({[tert-butyl (dimethyl)silyl]oxy}methyl)cyclobutyl]oxy}-N-(1-methyl-1H-pyrazol-3-yl)benzamide

: 1310807-65-8
3-{[1-({[tert-butyl (dimethyl)silyl]oxy}methyl)cyclobutyl]oxy}-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; under 3000.3 Torr;

Reference yield:

: 35120-18-4
ethyl 1-bromocyclobutane-1-carboxylate

: 1310807-65-8
3-{[1-({[tert-butyl (dimethyl)silyl]oxy}methyl)cyclobutyl]oxy}-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 35 h / 80 - 120 °C

2.1: sodium hydroxide / ethanol; water / 4 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 50 °C

3.2: 0.5 h / Cooling with ice

4.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3000.3 Torr

With 1H-imidazole; hydrogen; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 915771-04-9
3-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)-5-[(phenylmethyl)oxy]benzamide

: 1310807-65-8
3-{[1-({[tert-butyl (dimethyl)silyl]oxy}methyl)cyclobutyl]oxy}-5-hydroxy-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 35 h / 80 - 120 °C

2.1: sodium hydroxide / ethanol; water / 4 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 50 °C

3.2: 0.5 h / Cooling with ice

4.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3000.3 Torr

With 1H-imidazole; hydrogen; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;