5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid

Base Information

Chemical Name:5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid
CAS No.:1616924-48-1
Molecular Formula:C₂₇H₂₈N₂O₆
Molecular Weight:476.529
Hs Code.:

Synonyms:5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid

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Chemical Property of 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid

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Technology Process of 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid

There total 8 articles about 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.05%

: 1616924-47-0
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester

: 1616924-48-1
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; for 20h; Reflux;

Reference yield:

: 60356-11-8
cyano(1,4-dioxaspiro[4.5]dec-8-ylidene)acetic acid ethyl ester

: 1616924-48-1
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide / tetrahydrofuran; dibutyl ether / 2 h / -78 - -30 °C

1.2: 1 h / -78 - -30 °C

2.1: sodium iodide / dimethyl sulfoxide / 3 h / 150 °C / Sealed tube

2.2: 16 h / 20 °C

3.1: hydroxylamine / ethanol; water / 16 h / 60 °C

4.1: 16 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

6.1: sodium methylate / methanol / 16 h / 0 - 20 °C

7.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / Reflux

With copper(l) iodide; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium methylate; sodium iodide; In tetrahydrofuran; methanol; ethanol; dibutyl ether; water; dimethyl sulfoxide;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1616924-48-1
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid; ammonium acetate / toluene / 16 h / Dean-Stark; Reflux

2.1: copper(l) iodide / tetrahydrofuran; dibutyl ether / 2 h / -78 - -30 °C

2.2: 1 h / -78 - -30 °C

3.1: sodium iodide / dimethyl sulfoxide / 3 h / 150 °C / Sealed tube

3.2: 16 h / 20 °C

4.1: hydroxylamine / ethanol; water / 16 h / 60 °C

5.1: 16 h / 20 °C

6.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

7.1: sodium methylate / methanol / 16 h / 0 - 20 °C

8.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / Reflux

With copper(l) iodide; lithium hydroxide monohydrate; palladium 10% on activated carbon; ammonium acetate; hydrogen; hydroxylamine; sodium methylate; acetic acid; sodium iodide; In tetrahydrofuran; methanol; ethanol; dibutyl ether; water; dimethyl sulfoxide; toluene;