[5-(2-(4-benzoyl-phenyl)-1-{2-[tert-butoxycarbonyl-(2-{tert-butoxycarbonyl-[2-(isoquinoline-5-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethylcarbamoyl}-ethylcarbamoyl)-pentyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Name:[5-(2-(4-benzoyl-phenyl)-1-{2-[tert-butoxycarbonyl-(2-{tert-butoxycarbonyl-[2-(isoquinoline-5-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethylcarbamoyl}-ethylcarbamoyl)-pentyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:655224-12-7
Molecular Formula:C₆₂H₇₃N₇O₁₁S
Molecular Weight:1124.37
Hs Code.:

[5-(2-(4-benzoyl-phenyl)-1-{2-[<i>tert</i>-butoxycarbonyl-(2-{<i>tert</i>-butoxycarbonyl-[2-(isoquinoline-5-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethylcarbamoyl}-ethylcarbamoyl)-pentyl]-carbamic acid 9<i>H</i>-fluoren-9-ylmethyl ester

Synonyms:[5-(2-(4-benzoyl-phenyl)-1-{2-[tert-butoxycarbonyl-(2-{tert-butoxycarbonyl-[2-(isoquinoline-5-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethylcarbamoyl}-ethylcarbamoyl)-pentyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of [5-(2-(4-benzoyl-phenyl)-1-{2-[tert-butoxycarbonyl-(2-{tert-butoxycarbonyl-[2-(isoquinoline-5-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethylcarbamoyl}-ethylcarbamoyl)-pentyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of [5-(2-(4-benzoyl-phenyl)-1-{2-[tert-butoxycarbonyl-(2-{tert-butoxycarbonyl-[2-(isoquinoline-5-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethylcarbamoyl}-ethylcarbamoyl)-pentyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 9 articles about [5-(2-(4-benzoyl-phenyl)-1-{2-[tert-butoxycarbonyl-(2-{tert-butoxycarbonyl-[2-(isoquinoline-5-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethylcarbamoyl}-ethylcarbamoyl)-pentyl]-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 88574-06-5
6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid

: 655224-08-1
[2-({2-[2-amino-3-(4-benzoyl-phenyl)-propionylamino]-ethyl}-tert-butoxycarbonyl-amino)-ethyl]-[2-(isoquinoline-5-sulfonylamino)-ethyl]-carbamic acid tert-butyl ester

: 655224-12-7
[5-(2-(4-benzoyl-phenyl)-1-{2-[tert-butoxycarbonyl-(2-{tert-butoxycarbonyl-[2-(isoquinoline-5-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethylcarbamoyl}-ethylcarbamoyl)-pentyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1002/anie.200352084

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 655224-12-7
[5-(2-(4-benzoyl-phenyl)-1-{2-[tert-butoxycarbonyl-(2-{tert-butoxycarbonyl-[2-(isoquinoline-5-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethylcarbamoyl}-ethylcarbamoyl)-pentyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / CH₂Cl₂

2: 45 percent / N₂H₄*H₂O / CH₂Cl₂

3: 63 percent / Et₃N / CHCl₃

4: 68 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N-methylmorpholine; 1-hydroxy-1H-benzotriazole monohydrate / CH₂Cl₂

5: 85 percent / 4-(aminomethyl)piperidine / CH₂Cl₂

6: 52 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N-methylmorpholine; 1-hydroxy-1H-benzotriazole monohydrate / CH₂Cl₂

With 4-methyl-morpholine; 4-Aminomethylpiperidine; hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; chloroform;
DOI:10.1002/anie.200352084

Reference yield:

: 112-24-3
triethylentetramine

: 655224-12-7
[5-(2-(4-benzoyl-phenyl)-1-{2-[tert-butoxycarbonyl-(2-{tert-butoxycarbonyl-[2-(isoquinoline-5-sulfonylamino)-ethyl]-amino}-ethyl)-amino]-ethylcarbamoyl}-ethylcarbamoyl)-pentyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / dimethylformamide

2: 89 percent / CH₂Cl₂

3: 45 percent / N₂H₄*H₂O / CH₂Cl₂

4: 63 percent / Et₃N / CHCl₃

5: 68 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N-methylmorpholine; 1-hydroxy-1H-benzotriazole monohydrate / CH₂Cl₂

6: 85 percent / 4-(aminomethyl)piperidine / CH₂Cl₂

7: 52 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N-methylmorpholine; 1-hydroxy-1H-benzotriazole monohydrate / CH₂Cl₂

With 4-methyl-morpholine; 4-Aminomethylpiperidine; hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/anie.200352084