methyl 2-bromo-2-cyano-acetate

Base Information

• Chemical Name: methyl 2-bromo-2-cyano-acetate
• CAS No.: 31253-11-9
• Molecular Formula: C4H4 Br N O2
• Molecular Weight: 177.985
• Hs Code.: 2926909090
• Mol file: 31253-11-9.mol

Synonyms:Aceticacid, bromocyano-, methyl ester (8CI,9CI); Methyl bromocyanoacetate; NSC 75984

Chemical Property of methyl 2-bromo-2-cyano-acetate

Chemical Property:

• Vapor Pressure: 0.558mmHg at 25°C
• Boiling Point: 189.9°C at 760 mmHg
• Flash Point: 68.6°C
• PSA: 50.09000
• Density: 1.695g/cm³
• LogP: 0.44648

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-bromo-2-cyano-acetate

There total 5 articles about methyl 2-bromo-2-cyano-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

methyl 2-cyanoacetate (105-34-0) → methyl 2-bromo-2-cyanoacetate (31253-11-9)

Guidance literature:

With bromine; In tetrachloromethane; at 100 ℃; for 1h; Irradiation;

DOI:10.1055/s-1990-27009

Reference yield:

chloroform (67-66-3,8013-54-5) + 1-cyano-2,2-bis(methoxy)ethylene (15732-02-2) → methyl 2-bromo-2-cyanoacetate (31253-11-9) + 2-bromo-3,3-dimethoxy-acrylonitrile (857576-02-4) + methyl 2-cyanoacetate (105-34-0)

Guidance literature:

at -10 ℃;

DOI:10.1021/ja01127a057

Reference yield:

1-cyano-2,2-bis(methoxy)ethylene (15732-02-2) → methyl 2-bromo-2-cyanoacetate (31253-11-9)

Guidance literature:

With tetrachloromethane; bromine;

DOI:10.1021/ja01127a057

upstream raw materials:

1-cyano-2,2-bis(methoxy)ethylene

2-bromo-3,3-dimethoxy-acrylonitrile

acetic acid

methyl 2-cyanoacetate

Downstream raw materials:

dimethyl 2,3-dicyanofumarate

3,5-bis(2-(trifluoromethyl)phenyl)-1,2,4-thiadiazole

3,5-di-p-tolyl-[1,2,4]thiadiazole

3,5-bis-(4-methoxyphenyl)-[1,2,4]thiadiazole

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