Technology Process of (2R,3R)-3-(3-(benzyloxy)phenyl)-N,N,2-trimethylpent-4-en-1-amine
There total 8 articles about (2R,3R)-3-(3-(benzyloxy)phenyl)-N,N,2-trimethylpent-4-en-1-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,3R)-3-(3-benzyloxyphenyl)-N,N,2-trimethylpent-4-enamide;
With
sodium bis(2-methoxyethoxy)aluminium dihydride;
In
toluene;
at 50 - 100 ℃;
for 1h;
Inert atmosphere;
With
sodium hydroxide;
In
water; toluene;
at 20 ℃;
for 0.666667h;
Cooling with ice;
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 18 h / 20 - 40 °C / Inert atmosphere
2: bis(1,5-cyclooctadiene)diiridium(I) dichloride; tricyclohexylphosphine; sodium tetraphenyl borate / dichloromethane; acetone / 14 h / 20 °C / Inert atmosphere
3: 4-(dimethylamino)-N-((1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)picolinamide; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; triphenylborane / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere
4: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; triphenylborane; 4-(dimethylamino)-N-((1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)picolinamide; sodium tetraphenyl borate; sodium tris(acetoxy)borohydride; sodium hydride; tricyclohexylphosphine;
In
tetrahydrofuran; dichloromethane; acetone; mineral oil;
