10-acetyloxy-3-chloro-4-cyano-5-hydroxy-5,10-dihydrobenzo[b][1,6]naphthyridine

Base Information

• Chemical Name: 10-acetyloxy-3-chloro-4-cyano-5-hydroxy-5,10-dihydrobenzo[b][1,6]naphthyridine
• CAS No.: 494204-85-2
• Molecular Formula: C₁₅H₁₀ClN₃O₃
• Molecular Weight: 315.716
• Mol file: 494204-85-2.mol

Synonyms:10-acetyloxy-3-chloro-4-cyano-5-hydroxy-5,10-dihydrobenzo[b][1,6]naphthyridine

Chemical Property of 10-acetyloxy-3-chloro-4-cyano-5-hydroxy-5,10-dihydrobenzo[b][1,6]naphthyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-acetyloxy-3-chloro-4-cyano-5-hydroxy-5,10-dihydrobenzo[b][1,6]naphthyridine

There total 1 articles about 10-acetyloxy-3-chloro-4-cyano-5-hydroxy-5,10-dihydrobenzo[b][1,6]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

3-chloro-4-cyanobenzo<1,6>naphthyridine (104802-98-4) + acetic acid (64-19-7,77671-22-8) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → 3-chloro-4-cyano-10-oxo-5,10-dihydrobenzo[b][1,6]naphthyridine (532412-95-6) + 10-acetyloxy-3-chloro-4-cyano-5-hydroxy-5,10-dihydrobenzo[b][1,6]naphthyridine (494204-85-2) + 3-chloro-10-(3-chlorobenzoyloxy)-4-cyano-5-hydroxy-5,10-dihydrobenzo[b][1,6]naphthyridine (655240-71-4)

Guidance literature:

In water; at 20 ℃; for 2h;

DOI:10.1023/A:1024725811506

Reference yield: 71.0%

10-acetyloxy-3-chloro-4-cyano-5-hydroxy-5,10-dihydrobenzo[b][1,6]naphthyridine (494204-85-2) → 2-chloro-3-cyano-5-formyl-4-(2-hydroxyanilino)pyridine

Guidance literature:

With sodium hydroxide; In ethanol; at 0 ℃; for 1.5h;

DOI:10.1023/A:1021636632164

upstream raw materials:

3-chloro-4-cyanobenzo<1,6>naphthyridine

acetic acid

3-chloro-benzenecarboperoxoic acid