2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-butyric acid ethyl ester

Base Information

• Chemical Name: 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-butyric acid ethyl ester
• CAS No.: 113598-20-2
• Molecular Formula: C₁₉H₁₈ClNO₄
• Molecular Weight: 359.809

Synonyms:2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-butyric acid ethyl ester

Chemical Property of 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-butyric acid ethyl ester

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Technology Process of 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-butyric acid ethyl ester

There total 5 articles about 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

ethyl iodide (75-03-6) + TA-1801 (88352-44-7) → 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-butyric acid ethyl ester (113598-20-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; paraffin; 1.) -15 deg C, 2.) room temperature, 5 h;

DOI:10.1021/jm00401a021

Reference yield:

(furan-2-ylcarbonyl)methylamine hydrochloride (88352-86-7) → 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-butyric acid ethyl ester (113598-20-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / NaHCO₃ / H₂O; ethyl acetate / Ambient temperature

2: 70 percent / NaH / paraffin; dimethylformamide / 1.) -50 - -40 deg C, 20 min, 2.) -40 to 10 deg C, 30 min

3: 86 percent / phosphoryl chloride / dimethylformamide / 8 h / Ambient temperature

4: 47 percent / NaH / paraffin; dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 2.) room temperature, 5 h

With sodium hydride; sodium hydrogencarbonate; trichlorophosphate; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; paraffin;

DOI:10.1021/jm00401a021

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-butyric acid ethyl ester (113598-20-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / NaHCO₃ / H₂O; ethyl acetate / Ambient temperature

2: 70 percent / NaH / paraffin; dimethylformamide / 1.) -50 - -40 deg C, 20 min, 2.) -40 to 10 deg C, 30 min

3: 86 percent / phosphoryl chloride / dimethylformamide / 8 h / Ambient temperature

4: 47 percent / NaH / paraffin; dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 2.) room temperature, 5 h

With sodium hydride; sodium hydrogencarbonate; trichlorophosphate; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; paraffin;

DOI:10.1021/jm00401a021

upstream raw materials:

ethyl iodide

TA-1801

(furan-2-ylcarbonyl)methylamine hydrochloride

4-chloro-benzoyl chloride

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