N-[2-(tert-butoxycarbamoyl)ethyl]-N-(3-chlorophenyl)-2-chloroacetamide

Base Information

Chemical Name:N-[2-(tert-butoxycarbamoyl)ethyl]-N-(3-chlorophenyl)-2-chloroacetamide
CAS No.:183500-68-7
Molecular Formula:C₁₅H₂₀Cl₂N₂O₃
Molecular Weight:347.241
Hs Code.:

Synonyms:N-[2-(tert-butoxycarbamoyl)ethyl]-N-(3-chlorophenyl)-2-chloroacetamide

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Chemical Property of N-[2-(tert-butoxycarbamoyl)ethyl]-N-(3-chlorophenyl)-2-chloroacetamide

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Technology Process of N-[2-(tert-butoxycarbamoyl)ethyl]-N-(3-chlorophenyl)-2-chloroacetamide

There total 4 articles about N-[2-(tert-butoxycarbamoyl)ethyl]-N-(3-chlorophenyl)-2-chloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.6%

: 79-04-9
chloroacetyl chloride

: 183500-67-6
N-(tert-butoxycarbonyl)-N'-(3-chlorophenyl)-ethylenediamine

: 183500-68-7
N-[2-(tert-butoxycarbamoyl)ethyl]-N-(3-chlorophenyl)-2-chloroacetamide

Guidance literature:: N-(tert-butoxycarbonyl)-N'-(3-chlorophenyl)-ethylenediamine; With sodium hydrogencarbonate; In dichloromethane; at 0 ℃; for 0.166667h;

chloroacetyl chloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2014.12.036

Reference yield:

: 108-42-9
3-chloro-aniline

: 183500-68-7
N-[2-(tert-butoxycarbamoyl)ethyl]-N-(3-chlorophenyl)-2-chloroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3.1: sodium hydrogencarbonate / dichloromethane / 0.17 h / 0 °C

3.2: 20 °C

With lithium aluminium tetrahydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2014.12.036

Reference yield:

: 4530-20-5
BOC-glycine

: 183500-68-7
N-[2-(tert-butoxycarbamoyl)ethyl]-N-(3-chlorophenyl)-2-chloroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3.1: sodium hydrogencarbonate / dichloromethane / 0.17 h / 0 °C

3.2: 20 °C

With lithium aluminium tetrahydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2014.12.036