N-(3-bromo-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

Base Information

Chemical Name:N-(3-bromo-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide
CAS No.:1383852-02-5
Molecular Formula:C₂₂H₂₅BrFN₃O₂S
Molecular Weight:494.428
Hs Code.:

Synonyms:N-(3-bromo-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

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Chemical Property of N-(3-bromo-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

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Technology Process of N-(3-bromo-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

There total 5 articles about N-(3-bromo-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1383852-01-4
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-isopentylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylic acid

: 1383852-02-5
N-(3-bromo-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

Guidance literature:: With N-Bromosuccinimide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 1383852-00-3
methyl 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-isopentylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate

: 1383852-02-5
N-(3-bromo-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium trimethylsilonate / tetrahydrofuran / 3 h / Reflux

1.2: pH 3

2.1: N-Bromosuccinimide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h

With N-Bromosuccinimide; potassium trimethylsilonate; sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 42122-44-1
methyl 3-(4-fluorophenyl)propiolate

: 1383852-02-5
N-(3-bromo-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 18 h

2.1: [bis(acetoxy)iodo]benzene; potassium carbonate / dimethyl sulfoxide / 1 h

3.1: potassium trimethylsilonate / tetrahydrofuran / 3 h / Reflux

3.2: pH 3

4.1: N-Bromosuccinimide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h

With N-Bromosuccinimide; [bis(acetoxy)iodo]benzene; potassium trimethylsilonate; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;