N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

Base Information

Chemical Name:N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide
CAS No.:1383852-04-7
Molecular Formula:C₃₁H₄₂FN₅O₃SSi
Molecular Weight:611.856
Hs Code.:

N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

Synonyms:N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

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Chemical Property of N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

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Technology Process of N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

There total 8 articles about N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1383852-03-6
(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)zinc(II) chloride

: 1383852-02-5
N-(3-bromo-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

: 1383852-04-7
N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

Guidance literature:: With diisobutylaluminium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 120 ℃; for 42h; sealed tube;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1383852-04-7
N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h / 0 - 20 °C

1.2: 18 h / 20 °C

1.3: 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 42 h / 120 °C / sealed tube

With n-butyllithium; sodium hydride; diisobutylaluminium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; hexane; mineral oil;

Reference yield:

: 42122-44-1
methyl 3-(4-fluorophenyl)propiolate

: 1383852-04-7
N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 18 h

2.1: [bis(acetoxy)iodo]benzene; potassium carbonate / dimethyl sulfoxide / 1 h

3.1: potassium trimethylsilonate / tetrahydrofuran / 3 h / Reflux

3.2: pH 3

4.1: N-Bromosuccinimide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h

5.1: diisobutylaluminium hydride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 42 h / 120 °C / sealed tube

With N-Bromosuccinimide; [bis(acetoxy)iodo]benzene; potassium trimethylsilonate; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;