N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl]-N-(3-methylbutyl)methanesulfonamide

Base Information

Chemical Name:N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl]-N-(3-methylbutyl)methanesulfonamide
CAS No.:1383851-93-1
Molecular Formula:C₂₅H₂₈FN₅O₂S
Molecular Weight:481.594
Hs Code.:

Synonyms:N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl]-N-(3-methylbutyl)methanesulfonamide

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Chemical Property of N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl]-N-(3-methylbutyl)methanesulfonamide

Chemical Property:

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Technology Process of N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl]-N-(3-methylbutyl)methanesulfonamide

There total 7 articles about N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl]-N-(3-methylbutyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383852-04-7
N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl)-N-isopentylmethanesulfonamide

: 1383851-93-1
N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl]-N-(3-methylbutyl)methanesulfonamide

Guidance literature:: With hydrogenchloride; In ethanol; water; at 75 - 90 ℃; for 42h;

Reference yield:

: 42122-44-1
methyl 3-(4-fluorophenyl)propiolate

: 1383851-93-1
N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl]-N-(3-methylbutyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 18 h

2.1: [bis(acetoxy)iodo]benzene; potassium carbonate / dimethyl sulfoxide / 1 h

3.1: potassium trimethylsilonate / tetrahydrofuran / 3 h / Reflux

3.2: pH 3

4.1: N-Bromosuccinimide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h

5.1: diisobutylaluminium hydride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 42 h / 120 °C / sealed tube

6.1: hydrogenchloride / ethanol; water / 42 h / 75 - 90 °C

With hydrogenchloride; N-Bromosuccinimide; [bis(acetoxy)iodo]benzene; potassium trimethylsilonate; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1383851-93-1
N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-6-yl]-N-(3-methylbutyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C

1.2: 18.5 h / -78 - 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 18 h

3.1: [bis(acetoxy)iodo]benzene; potassium carbonate / dimethyl sulfoxide / 1 h

4.1: potassium trimethylsilonate / tetrahydrofuran / 3 h / Reflux

4.2: pH 3

5.1: N-Bromosuccinimide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h

6.1: diisobutylaluminium hydride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 42 h / 120 °C / sealed tube

7.1: hydrogenchloride / ethanol; water / 42 h / 75 - 90 °C

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; [bis(acetoxy)iodo]benzene; potassium trimethylsilonate; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;